Transcription factor brachyury, with a DNA-binding T-domain, regulates posterior mesoderm
formation and notochord development through binding with highly conserved palindromic …

Transcription factors (TFs) are DNA-binding proteins able to modulate the timing, location,
and levels of gene expression by binding to regulatory DNA regions. Therefore, the …

Tissue-specific gene expression is fundamental in development and evolution, and is
mediated by transcription factors and by the cis-regulatory regions (enhancers) that they …

Zygotic genome activation (ZGA) is a major genome programming event whereby the cells
of the embryo begin to adopt specified fates. Experiments in Drosophila and zebrafish have …

Transcription factors are crucial drivers of cellular differentiation during animal development
and often share ancient evolutionary origins. The T-box transcription factor Brachyury plays …

The notochord is a defining feature of all chordates. The transcription factors Zic and ETS
regulate enhancer activity within the notochord. We conduct high-throughput screens of …

T-box proteins are key developmental transcription factors in Metazoa. Until recently they
were thought to be animal specific and many T-box classes were considered bilaterian …

For more than a century, studies on tunicate muscle formation have revealed many
principles of cell fate specification, gene regulation, morphogenesis, and evolution. Here, we …

The notochord is a structure required for support and patterning of all chordate embryos,
from sea squirts to humans. An increasing amount of information on notochord development …

The notochord of the ascidian Ciona consists of only 40 cells, and is a longstanding model
for studying organogenesis in a small, simple embryo. Here, we perform RNAseq on flow …