The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

The actin cytoskeleton is a complex structure that performs a wide range of cellular
functions. In 2001, significant advances were made to our understanding of the structure and …

Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium
not secondary to ischemic, hypertensive, or valvular heart disease. ACM incorporates a …

The Association for European Cardiovascular Pathology and the Society for Cardiovascular
Pathology have produced this position paper concerning the current role of endomyocardial …

Desmosomes are major cell adhesion junctions, particularly prominent in the epidermis and
cardiac tissue and are important for the rigidity and strength of the cells. The desmosome …

Given the global burden of heart failure, strategies to understand the underlying cause or to
provide prognostic information are critical to reducing the morbidity and mortality associated …

Background The molecular basis of idiopathic dilated cardiomyopathy, a primary myocardial
disorder that results in reduced contractile function, is largely unknown. Some cases of …

Background: Filamin C (encoded by the FLNC gene) is essential for sarcomere attachment
to the plasmatic membrane. FLNC mutations have been associated with myofibrillar …

For many neuromuscular diseases (NMDs), cardiac disease represents a major cause of
morbidity and mortality. The management of cardiac disease in NMDs is made challenging …

Intermediate filaments provide scaffolding for the cell and protect it against stress. This
comprehensive review points out that there are more than 100 intermediate filament genes …