Non-small-cell lung cancers: a heterogeneous set of diseases
Non-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have
diverse pathological features. During the past decade, in-depth analyses of lung cancer …
diverse pathological features. During the past decade, in-depth analyses of lung cancer …
Molecular mechanisms of chemo‐and radiotherapy resistance and the potential implications for cancer treatment
YP Liu, CC Zheng, YN Huang, ML He, WW Xu… - MedComm, 2021 - Wiley Online Library
Cancer is a leading cause of death worldwide. Surgery is the primary treatment approach for
cancer, but the survival rate is very low due to the rapid progression of the disease and …
cancer, but the survival rate is very low due to the rapid progression of the disease and …
[HTML][HTML] Immunogenic chemotherapy sensitizes tumors to checkpoint blockade therapy
C Pfirschke, C Engblom, S Rickelt, V Cortez-Retamozo… - Immunity, 2016 - cell.com
Checkpoint blockade immunotherapies can be extraordinarily effective, but might benefit
only the minority of patients whose tumors are pre-infiltrated by T cells. Here, using lung …
only the minority of patients whose tumors are pre-infiltrated by T cells. Here, using lung …
Emergence of a high-plasticity cell state during lung cancer evolution
ND Marjanovic, M Hofree, JE Chan, D Canner, K Wu… - Cancer cell, 2020 - cell.com
Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly
understood. Here, we profile single-cell transcriptomes of genetically engineered mouse …
understood. Here, we profile single-cell transcriptomes of genetically engineered mouse …
[HTML][HTML] ATM and ATR as therapeutic targets in cancer
AM Weber, AJ Ryan - Pharmacology & therapeutics, 2015 - Elsevier
In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …
DNA repair pathways in cancer therapy and resistance
L Li, Y Guan, X Chen, J Yang, Y Cheng - Frontiers in pharmacology, 2021 - frontiersin.org
DNA repair pathways are triggered to maintain genetic stability and integrity when
mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The …
mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The …
Integrated magneto–electrochemical sensor for exosome analysis
Extracellular vesicles, including exosomes, are nanoscale membrane particles that carry
molecular information on parental cells. They are being pursued as biomarkers of cancers …
molecular information on parental cells. They are being pursued as biomarkers of cancers …
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance
P Bouwman, J Jonkers - Nature Reviews Cancer, 2012 - nature.com
Tumours with specific DNA repair defects can be completely dependent on back-up DNA
repair pathways for their survival. This dependence can be exploited therapeutically to …
repair pathways for their survival. This dependence can be exploited therapeutically to …
MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to aurora kinase inhibition
Loss of the tumor suppressors RB1 and TP53 and MYC amplification are frequent
oncogenic events in small cell lung cancer (SCLC). We show that Myc expression …
oncogenic events in small cell lung cancer (SCLC). We show that Myc expression …
Selective killing of ATM-or p53-deficient cancer cells through inhibition of ATR
PM Reaper, MR Griffiths, JM Long, JD Charrier… - Nature chemical …, 2011 - nature.com
Here we report a comprehensive biological characterization of a potent and selective small-
molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound …
molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound …