Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

▪ Abstract Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially
discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide …

Nitric oxide (NO) has been linked to numerous physiological and pathophysiological events
that are not readily explained by the well established effects of NO on soluble guanylyl …

Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

The dentate gyrus provides the main input to the hippocampus. Information reaches the CA3
region through mossy fibre synapses made by dentate granule cell axons. Synaptic plasticity …

Hyperpolarization‐activated cation currents (Ih) contribute to various physiological
properties and functions in the brain, including neuronal pacemaker activity, setting of …

Spatio-temporal configurations of distributed activity in the brain is thought to contribute to
the coding of neuronal information and synaptic contacts between nerve cells could play a …

Stimulus-secretion coupling is an essential process in secretory cells in which regulated
exocytosis occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While …

The hyperpolarization-activated cation current (termed I h, I q, or I f) was recently shown to
be encoded by a new family of genes, named HCN for h yperpolarization-activated c yclic n …