Amyloid formation as a protein phase transition

TCT Michaels, D Qian, A Šarić, M Vendruscolo… - Nature Reviews …, 2023‏ - nature.com
The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders …

Liquid phase condensation in cell physiology and disease

Y Shin, CP Brangwynne - Science, 2017‏ - science.org
BACKGROUND Living cells contain distinct subcompartments to facilitate spatiotemporal
regulation of biological reactions. In addition to canonical membrane-bound organelles such …

Droplet physics and intracellular phase separation

F Jülicher, CA Weber - Annual Review of Condensed Matter …, 2024‏ - annualreviews.org
Living cells are spatially organized by compartments that can nucleate, grow, and dissolve.
Compartmentalization can emerge by phase separation, leading to the formation of droplets …

Higher-order organization of biomolecular condensates

CM Fare, A Villani, LE Drake, J Shorter - Open biology, 2021‏ - royalsocietypublishing.org
A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …

Physical principles of intracellular organization via active and passive phase transitions

J Berry, CP Brangwynne… - Reports on Progress in …, 2018‏ - iopscience.iop.org
Exciting recent developments suggest that phase transitions represent an important and
ubiquitous mechanism underlying intracellular organization. We describe key experimental …

Physics of active emulsions

CA Weber, D Zwicker, F Jülicher… - Reports on Progress in …, 2019‏ - iopscience.iop.org
Phase separating systems that are maintained away from thermodynamic equilibrium via
molecular processes represent a class of active systems, which we call active emulsions …

Theoretical and data-driven approaches for biomolecular condensates

KL Saar, D Qian, LL Good, AS Morgunov… - Chemical …, 2023‏ - ACS Publications
Biomolecular condensation processes are increasingly recognized as a fundamental
mechanism that living cells use to organize biomolecules in time and space. These …

The intertwined physics of active chemical reactions and phase separation

D Zwicker - Current Opinion in Colloid & Interface Science, 2022‏ - Elsevier
Phase separation is the thermodynamic process that explains how droplets form in
multicomponent fluids. These droplets can provide controlled compartments to localize …

Theories for sequence-dependent phase behaviors of biomolecular condensates

YH Lin, JD Forman-Kay, HS Chan - Biochemistry, 2018‏ - ACS Publications
Liquid–liquid phase separation and related condensation processes of intrinsically
disordered proteins (IDPs), proteins with intrinsically disordered regions, and nucleic acids …

Phase transition of the largest eigenvalue for nonnull complex sample covariance matrices

J Baik, G Ben Arous, S Péché - 2005‏ - projecteuclid.org
We compute the limiting distributions of the largest eigenvalue of a complex Gaussian
sample covariance matrix when both the number of samples and the number of variables in …