In the past decade, increasing efforts have been devoted to the study of galectins, a family of
evolutionarily conserved glycan-binding proteins with multifunctional properties. Galectins …

Galectins are characterized by their binding affinity for β-galactosides, a unique binding site
sequence motif, and wide taxonomic distribution and structural conservation in vertebrates …

Galectin 1 (Gal-1), a β-galactoside binding mammalian lectin of 14KDa, is implicated in
many signalling pathways, immune responses associated with cancer progression and …

Galectins represent β-galactoside-binding proteins and are known to bind Galβ1-3/4GlcNAc
disaccharides (abbreviated as LN1 and LN2, respectively). Despite high sequence and …

Although lectins are “hard‐wired” in the germline, the presence of tandemly arrayed
carbohydrate recognition domains (CRDs), of chimeric structures displaying distinct CRDs …

Recognition and complex formation between proteins and carbohydrates is a key issue in
many important biological processes. Determination of the three-dimensional structure of …

Galectin-1 (Gal-1), a 14kDa carbohydrate-binding protein of the galectin family found in
humans, affects intracellular signaling pathways upon interaction with β-galactosides on cell …

Human Galectin-8 (Gal-8) is a member of the galectin family which shares an affinity for β-
galactosides. The tandem-repeat Gal-8 consists of a N-and a C-terminal carbohydrate …

Sugar mimics are valuable tools in medicinal chemistry, offering the potential to overcome
the limitations of carbohydrate inhibitors, such as poor pharmacokinetics and non-selectivity …

Endogenous lectins can control critical biological responses, including cell communication,
signaling, angiogenesis and immunity by decoding glycan-containing information on a …