The machinery of exosomes: biogenesis, release, and uptake

SV Krylova, D Feng - International Journal of Molecular Sciences, 2023 - mdpi.com
Exosomes are a subtype of membrane-contained vesicles 40–200 nm in diameter that are
secreted by cells into their surroundings. By transporting proteins, lipids, mRNA, miRNA …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

[HTML][HTML] Exosome theranostics: biology and translational medicine

C He, S Zheng, Y Luo, B Wang - Theranostics, 2018 - ncbi.nlm.nih.gov
Exosomes are common membrane-bound nanovesicles that contain diverse biomolecules,
such as lipids, proteins, and nucleic acids. Exosomes are derived from cells through …

The role of exosomes in cancer metastasis

TB Steinbichler, J Dudás, H Riechelmann… - Seminars in cancer …, 2017 - Elsevier
Exosomes are small membrane vesicles with a size ranging from 40 to 100 nm. They can
serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a …

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

JC Akers, D Gonda, R Kim, BS Carter… - Journal of neuro …, 2013 - Springer
Recent studies suggest both normal and cancerous cells secrete vesicles into the
extracellular space. These extracellular vesicles (EVs) contain materials that mirror the …

[HTML][HTML] The ESCRT pathway

WM Henne, NJ Buchkovich, SD Emr - Developmental cell, 2011 - cell.com
Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or
lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key …

Exosomes: composition, biogenesis and function

C Théry, L Zitvogel, S Amigorena - Nature reviews immunology, 2002 - nature.com
Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells
in culture. Interest in exosomes has intensified after their recent description in antigen …

Signals for sorting of transmembrane proteins to endosomes and lysosomes

JS Bonifacino, LM Traub - Annual review of biochemistry, 2003 - annualreviews.org
▪ Abstract Sorting of transmembrane proteins to endosomes and lysosomes is mediated by
signals present within the cytosolic domains of the proteins. Most signals consist of short …

Exosomes: endosomal-derived vesicles ship** extracellular messages

B Février, G Raposo - Current opinion in cell biology, 2004 - Elsevier
Exosomes are membrane vesicles released into the extracellular environment upon exocytic
fusion of multivesicular endosomes with the cell surface. They have a particular composition …

Proteomic and biochemical analyses of human B cell-derived exosomes: potential implications for their function and multivesicular body formation

R Wubbolts, RS Leckie, PTM Veenhuizen… - Journal of Biological …, 2003 - ASBMB
Exosomes are 60–100-nm membrane vesicles that are secreted into the extracellular milieu
as a consequence of multivesicular body fusion with the plasma membrane. Here we …