New therapies on the horizon: Targeted protein degradation in neuroscience
This minireview explores the burgeoning field of targeted protein degradation (TPD) and its
promising applications in neuroscience and clinical development. TPD offers innovative …
promising applications in neuroscience and clinical development. TPD offers innovative …
Deep learning facilitates efficient optimization of antisense oligonucleotide drugs
Nucleic acid therapeutics exert their therapeutic effects by targeting specific genes through
complementary sequence recognition to inhibit the expression of certain proteins or facilitate …
complementary sequence recognition to inhibit the expression of certain proteins or facilitate …
[HTML][HTML] Convergence on CaMK4: a key modulator of autism-associated signaling pathways in neurons
J Kaiser, A Risteska, AG Muller, H Sun, B Lei, K Nay… - Biological …, 2024 - Elsevier
Although the precise underlying cause (s) of autism spectrum disorder remain unclear, more
than 1000 rare genetic variations are associated with the condition. For a large number of …
than 1000 rare genetic variations are associated with the condition. For a large number of …
Male proband with intractable seizures and a de novo start codon disrupting variant in GLUL
Biallelic variants in GLUL, encoding glutamine synthetase and responsible for the
conversion of glutamate to glutamine, are associated with a severe recessive disease due to …
conversion of glutamate to glutamine, are associated with a severe recessive disease due to …
[PDF][PDF] Streamlining Drug Repurposing: Optimizing Candidate Prioritization to Facilitate Clinical Adoption and Minimize Attrition Rates
Drug repurposing, identifying FDA-approved drugs for new indications, reduces the time and
money required for a drug to reach the clinic and capitalizes on the increasing number of …
money required for a drug to reach the clinic and capitalizes on the increasing number of …