Nanotechnology-based ocular drug delivery systems: recent advances and future prospects
S Li, L Chen, Y Fu - Journal of Nanobiotechnology, 2023 - Springer
Ocular drug delivery has constantly challenged ophthalmologists and drug delivery
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …
The role of trained immunity in COVID-19: Lessons for the next pandemic
Trained immunity is a long-term increase in responsiveness of innate immune cells, induced
by certain infections and vaccines. During the last 3 years of the COVID-19 pandemic …
by certain infections and vaccines. During the last 3 years of the COVID-19 pandemic …
Bacterial-induced or passively administered interferon gamma conditions the lung for early control of SARS-CoV-2
Abstract Type-1 and type-3 interferons (IFNs) are important for control of viral replication;
however, less is known about the role of Type-2 IFN (IFNγ) in anti-viral immunity. We …
however, less is known about the role of Type-2 IFN (IFNγ) in anti-viral immunity. We …
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections
The innate immune system is able to build memory-like features in response to certain
infections or vaccines, resulting in enhanced responsiveness upon (re) challenge with the …
infections or vaccines, resulting in enhanced responsiveness upon (re) challenge with the …
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection
Abstract TANK-binding kinase 1 (TBK1) is a key signalling component in the production of
type-I interferons, which have essential antiviral activities, including against SARS-CoV-2 …
type-I interferons, which have essential antiviral activities, including against SARS-CoV-2 …
Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients
Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-
2 monoclonal antibodies and vaccines currently used in clinical practice; broadly …
2 monoclonal antibodies and vaccines currently used in clinical practice; broadly …
Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge
In addition to providing partial protection against pediatric tuberculosis, vaccination with
bacille Calmette-Guérin (BCG) has been reported to confer nonspecific resistance to …
bacille Calmette-Guérin (BCG) has been reported to confer nonspecific resistance to …
Interpreting the results of trials of BCG vaccination for protection against COVID-19
BCG vaccination has beneficial off-target (“nonspecific”) effects on nonmycobacterial
infections. On this premise, trials set out to investigate whether BCG provides off-target …
infections. On this premise, trials set out to investigate whether BCG provides off-target …
[HTML][HTML] Mucosal COVID-19 vaccines: Risks, benefits and control of the pandemic
D Miteva, M Peshevska-Sekulovska… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Based on mucosal immunization to promote both mucosal and systemic immune responses,
next-generation coronavirus disease 2019 (COVID-19) vaccines would be administered …
next-generation coronavirus disease 2019 (COVID-19) vaccines would be administered …
Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian …
This proof-of-concept study tested if prior BCG revaccination can qualitatively and
quantitively enhance antibody and T-cell responses induced by Oxford/AstraZeneca …
quantitively enhance antibody and T-cell responses induced by Oxford/AstraZeneca …