Genophenotypic factors and pharmacogenomics in adverse drug reactions
R Cacabelos, V Naidoo, L Corzo, N Cacabelos… - International journal of …, 2021 - mdpi.com
Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …
illness in developed countries. ADRs show differential features depending upon genotype …
Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a clear sex
disparity in clinical outcomes. Hence, the interaction between sex hormones, virus entry …
disparity in clinical outcomes. Hence, the interaction between sex hormones, virus entry …
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling
Vascular endothelial cells (ECs) form a critical interface between blood and tissues that
maintains whole-body homeostasis. In COVID-19, disruption of the EC barrier results in …
maintains whole-body homeostasis. In COVID-19, disruption of the EC barrier results in …
Association of TMPRSS2 Gene Polymorphisms with COVID-19 Severity and Mortality: a Case-Control Study with Computational Analyses
Abstract Coronavirus disease 2019 (COVID-19) is a severe disease caused by a new
variant of beta-coronavirus that first appeared in China. Human genetic factors, including …
variant of beta-coronavirus that first appeared in China. Human genetic factors, including …
Molecular insights into SARS-CoV2-induced alterations of the gut/brain axis
S Nataf, L Pays - International Journal of Molecular Sciences, 2021 - mdpi.com
For a yet unknown reason, a substantial share of patients suffering from COVID-19 develop
long-lasting neuropsychiatric symptoms ranging from cognitive deficits to mood disorders …
long-lasting neuropsychiatric symptoms ranging from cognitive deficits to mood disorders …
Gut-brain communication in COVID-19: molecular mechanisms, mediators, biomarkers, and therapeutics
Introduction Infection with COVID-19 results in acute respiratory symptoms followed by long
COVID multi-organ effects presenting with neurological, cardiovascular, musculoskeletal …
COVID multi-organ effects presenting with neurological, cardiovascular, musculoskeletal …
Human genetic basis of severe or critical illness in COVID-19
XS Ji, B Chen, B Ze, WH Zhou - Frontiers in cellular and infection …, 2022 - frontiersin.org
Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has led to considerable morbidity and mortality …
syndrome coronavirus 2 (SARS-CoV-2) has led to considerable morbidity and mortality …
IFITM3, FURIN, ACE1, and TNF-α Genetic Association With COVID-19 Outcomes: Systematic Review and Meta-Analysis
JLF de Araújo, D Menezes, RS Aguiar… - Frontiers in …, 2022 - frontiersin.org
Human polymorphisms may contribute to SARS-CoV-2 infection susceptibility and COVID-
19 outcomes (asymptomatic presentation, severe COVID-19, death). We aimed to evaluate …
19 outcomes (asymptomatic presentation, severe COVID-19, death). We aimed to evaluate …
[HTML][HTML] Interactions of renin-angiotensin system and COVID-19: the importance of daily rhythms in ACE2, ADAM17 and TMPRSS2 expression
Summary Angiotensin-converting enzyme 2 (ACE2) was identified as a molecule that
mediates the cellular entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
mediates the cellular entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
rs12329760 polymorphism in transmembrane serine protease 2 gene and risk of coronavirus disease 2019 mortality
SS Beheshti Shirazi, F Sakhaee… - BioMed Research …, 2022 - Wiley Online Library
The protease produced by the transmembrane serine protease 2 (TMPRSS2) gene
enhances viral infections and has been linked to severe acute respiratory syndrome …
enhances viral infections and has been linked to severe acute respiratory syndrome …