NSAIDS: old acquaintance in the pipeline for cancer treatment and Prevention─ Structural modulation, mechanisms of action, and bright future

S Ramos-Inza, AC Ruberte, C Sanmartin… - Journal of Medicinal …, 2021 - ACS Publications
The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent

P Pantziarka, V Sukhatme, G Bouche… - …, 2016 - pmc.ncbi.nlm.nih.gov
Diclofenac (DCF) is a well-known and widely used non-steroidal anti-inflammatory drug
(NSAID), with a range of actions which are of interest in an oncological context. While there …

[HTML][HTML] Diclofenac N-derivatives as therapeutic agents with anti-inflammatory and anti-cancer effect

A Galisteo, F Jannus, A García-García… - International Journal of …, 2021 - mdpi.com
A series of diclofenac N-derivatives (2, 4, 6, 8c, 9c, 10a-c) were synthesized in order to test
their anti-cancer and anti-inflammatory effects. The anticarcinogen activity has been …

[HTML][HTML] Conjugation of diclofenac with novel oleanolic acid derivatives modulate Nrf2 and NF-κB activity in hepatic cancer cells and normal hepatocytes leading to …

M Narożna, V Krajka-Kuźniak, B Bednarczyk-Cwynar… - Pharmaceuticals, 2021 - mdpi.com
Combining NSAIDs with conventional therapeutics was recently explored as a new strategy
in cancer therapy. Our earlier studies showed that novel oleanolic acid oximes (OAO) …

[HTML][HTML] Diclofenac potentiates sorafenib-based treatments of hepatocellular carcinoma by enhancing oxidative stress

AP Duval, L Troquier, O de Souza Silva, N Demartines… - Cancers, 2019 - mdpi.com
Sorafenib is the first developed systemic treatment for advanced forms of hepatocellular
carcinoma, which constitutes the most frequent form of primary liver cancers and is a major …

Exciton emission of quasi-2D InGaN in GaN matrix grown by molecular beam epitaxy

D Ma, X Rong, X Zheng, W Wang, P Wang, T Schulz… - Scientific reports, 2017 - nature.com
We investigate the emission from confined excitons in the structure of a single-monolayer-
thick quasi-two-dimensional (quasi-2D) InxGa1− xN layer inserted in GaN matrix. This quasi …

Cytotoxic and antiproliferative effects of the nonsteroidal anti-inflammatory drug diclofenac in human tumour cell lines

L Marinov, A Georgieva, Y Voynikov… - Biotechnology & …, 2021 - Taylor & Francis
Diclofenac is one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs) for
acute and chronic inflammatory conditions. Taking into consideration the extensive use of …

Combinatorial effect of diclofenac with piperine and D-limonene on inducing apoptosis and cell cycle arrest of breast cancer cells

S Sankar, GK Muthukaliannan - Asian Pacific Journal of Tropical …, 2023 - journals.lww.com
Objective: To investigate the potential synergistic activity of diclofenac with piperine and D-
limonene in inducing apoptosis and cell cycle arrest in breast cancer MCF-7 cells. Methods …

CSN5 silencing reverses sorafenib resistance of human hepatocellular carcinoma HepG2 cells

H Wang, Z Qian, H Zhao, X Zhang… - Molecular …, 2015 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is one of the most common tumor types, and is the third
leading cause of cancer mortalities worldwide. A large number of patients with HCC are …

Serum DLAT Is a Potential Diagnostic Marker in AFP-Negative HCC

F Huang, J Bai, L Hu, C Luo, L Ning - Biological and Pharmaceutical …, 2024 - jstage.jst.go.jp
The aim of this study was to analyze dihydrolipoyllysine-residue acetyltransferase (DLAT)
expression and diagnostic ability in hepatocellular carcinoma (HCC), assess its role in HCC …