Alterations in intestinal structure, mechanics and physiology underlie acute and chronic
intestinal conditions, many of which are influenced by dysregulation of microbiome …

Project Optimus is a US Food and Drug Administration Oncology Center of Excellence
initiative aimed at reforming the dose selection and optimization paradigm in oncology drug …

Disease models enable researchers to investigate, test, and identify therapeutic targets that
would alter the patients' disease condition and improve quality of life. Advances in genetic …

Rapid advances in tissue engineering have resulted in more complex and physiologically
relevant 3D in vitro tissue models with applications in fundamental biology and therapeutic …

During the past 15 years, a plethora of innovative 3D in vitro systems has been developed.
They offer the possibility of identifying crucial cellular and molecular contributors to the …

Digestive system cancers account for nearly half of all cancers around the world and have a
high mortality rate. Cell culture and animal models represent cornerstones of digestive …

Simple Summary The word “model” can be used with different meanings and different
contexts, like a model student, clay models or a model railway. In some cases, the context …

Regulatory authorities and pharmaceutical companies in Europe and the United States have
paid attention to microphysiological systems (MPS), and various consortia and academic …

The present work focuses on a non-local integro-differential model reproducing Cancer-on-
chip experiments where tumor cells, treated with chemotherapy drugs, secrete chemical …

in real-world drug research, and, in turn, facilitate insight and guidance for future research in
quantitative pharmacological modeling and simulation. Presented as a high-level overview …