Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Melanogenesis is a complex process in which melanin is synthesized in melanocytes and
transported to keratinocytes, which involves multiple genes and signaling pathways …

During tumor progression, cancer cells come into contact with various non-tumor cell types,
but it is unclear how tumors adapt to these new environments. Here, we integrate spatially …

Somatic hotspot mutations and structural amplifications and fusions that affect fibroblast
growth factor receptor 2 (encoded by FGFR2) occur in multiple types of cancer. However …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Methylation of DNA at CpG sites is the most common and stable of epigenetic changes in
cancer. Hypermethylation acts to limit immune checkpoint blockade immunotherapy by …

Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Cancer was thought to be caused solely by genetic mutations in oncogenes and tumor
suppressor genes. In the last 35 years, however, epigenetic changes have been …

Exosomal microRNAs (miRNAs) have been implicated in the development and progression
of a variety of tumors; however, whether they contribute to medulloblastoma (MB) …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …