PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
Small non-coding RNA and cancer
The ENCODE project has reported that at least 80% of the human genome is biologically
active, yet only a small part of human DNA encodes for protein. The massive amount of RNA …
active, yet only a small part of human DNA encodes for protein. The massive amount of RNA …
One loop to rule them all: the **-pong cycle and piRNA-guided silencing
The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects
the genetic information of animal germ cells from the deleterious effects of molecular …
the genetic information of animal germ cells from the deleterious effects of molecular …
RISC assembly: Coordination between small RNAs and Argonaute proteins
H Kobayashi, Y Tomari - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …
piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production
PIWI-interacting RNAs (piRNAs) protect the animal germ line by silencing transposons.
Primary piRNAs, generated from transcripts of genomic transposon “junkyards”(piRNA …
Primary piRNAs, generated from transcripts of genomic transposon “junkyards”(piRNA …
piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis
In animal gonads, PIWI-clade Argonaute proteins repress transposons sequence-
specifically via bound Piwi-interacting RNAs (piRNAs). These are processed from single …
specifically via bound Piwi-interacting RNAs (piRNAs). These are processed from single …
[HTML][HTML] Single-molecule imaging reveals that argonaute reshapes the binding properties of its nucleic acid guides
Argonaute proteins repress gene expression and defend against foreign nucleic acids using
short RNAs or DNAs to specify the correct target RNA or DNA sequence. We have …
short RNAs or DNAs to specify the correct target RNA or DNA sequence. We have …
Relaxed targeting rules help PIWI proteins silence transposons
In eukaryotes, small RNA guides, such as small interfering RNAs and microRNAs, direct
AGO-clade Argonaute proteins to regulate gene expression and defend the genome against …
AGO-clade Argonaute proteins to regulate gene expression and defend the genome against …
Identification of piRNA binding sites reveals the argonaute regulatory landscape of the C. elegans germline
Summary piRNAs (Piwi-interacting small RNAs) engage Piwi Argonautes to silence
transposons and promote fertility in animal germlines. Genetic and computational studies …
transposons and promote fertility in animal germlines. Genetic and computational studies …
The genomes of all lungfish inform on genome expansion and tetrapod evolution
The genomes of living lungfishes can inform on the molecular-developmental basis of the
Devonian sarcopterygian fish–tetrapod transition. We de novo sequenced the genomes of …
Devonian sarcopterygian fish–tetrapod transition. We de novo sequenced the genomes of …