Electrochemical C−H deuteration of pyridine derivatives with D2O

Z Zhao, R Zhang, Y Liu, Z Zhu, Q Wang… - Nature Communications, 2024 - nature.com
Herein, we develop a straightforward, metal-free, and acid-/base-free electrochemical C4-
selective C− H deuteration of pyridine derivatives with economic and convenient D2O at …

Electroreductive Cross-Coupling Reactions: Carboxylation, Deuteration, and Alkylation

P Li, Y Wang, H Zhao, Y Qiu - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus Electrochemistry has been used as a tool to drive chemical reactions for more
than two centuries. With the help of an electrode and a power source, chemists are provided …

When transition-metal catalysis meets electrosynthesis: a recent update

F Lian, JL Li, K Xu - Organic & Biomolecular Chemistry, 2024 - pubs.rsc.org
While aiming at sustainable synthesis, organic electrosynthesis has attracted increasing
attention in the past few years. In parallel, with a deeper understanding of catalyst and …

Reductive alkyl–alkyl coupling from isolable nickel–alkyl complexes

S Al Zubaydi, S Waske, V Akyildiz, HF Starbuck… - Nature, 2024 - nature.com
The selective cross-coupling of two alkyl electrophiles to construct complex molecules
remains a challenge in organic synthesis,. Known reactions are optimized for specific …

Electrochemical Glycosylation via Halogen-Atom-Transfer for C-Glycoside Assembly

J Wu, R Purushothaman, F Kallert, SL Homölle… - ACS …, 2024 - ACS Publications
Glycosyl donor activation emerged as an enabling technology for anomeric
functionalization, but aimed primarily at O-glycosylation. In contrast, we herein disclose …

Photoelectrochemical Ni-catalyzed cross-coupling of aryl bromides with amine at ultra-low potential

J Wang, S Li, C Yang, H Gao, L Zuo, Z Guo… - Nature …, 2024 - nature.com
Photoelectrochemical (PEC) cell is an ideal platform for organic transformation because of
its green benefits and minimal energy consumption. As an emerging methodology, the …

Electrochemical conversion of organic compounds and inorganic small molecules

W Zeng, Y Qiu - Science China Chemistry, 2024 - Springer
Electrochemical synthesis presents a facile and sustainable strategy to produce valuable
molecules. This review summarizes the most recent advances in electrosynthesizing value …

Iron-Catalyzed Cross-Electrophile Coupling for the Formation of All-Carbon Quaternary Centers

AL Pace, F Xu, W Liu, MN Lavagnino… - Journal of the …, 2024 - ACS Publications
Quaternary carbon centers are desirable targets for drug discovery and complex molecule
synthesis, yet the synthesis of these motifs within traditional cross-coupling paradigms …

Sacrificial anode-free electrochemical cross-electrophile coupling of 1, 3-diol derivatives to form aliphatic and aryl cyclopropanes

N Hirbawi, ETA Raffman, JR Pedroarena… - Organic …, 2024 - ACS Publications
Cross-electrophile coupling reactions that forge C (sp3)–C (sp3) bonds are strategic
methods for the synthesis of molecules with high F (sp3), yet very few employ …

Electrochemical Construction of Contiguous Quaternary Centers

G Kou, P Li, G Yang, Y Qiu - CCS Chemistry, 2024 - chinesechemsoc.org
The presence of vicinal quaternary carbon centers within biologically active molecules is
widespread, yet conventional synthetic routes often necessitate intricate substrate …