The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation
of immune responses associated with a broad range of diseases, including autoimmunity …

Monocytes and macrophages may either promote or down-regulate inflammatory reactions
depending on their state of activation. The effects of glucocorticoids (GCs), the most widely …

Autoimmune responses are normally kept in check by immune-tolerance mechanisms,
which include regulatory T cells. In recent years, research has focused on the role of a …

CD1-and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …

Systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) of the skin are
autoimmune diseases characterized by inappropriate immune responses against self …

Natural killer T (NKT) cells are an unusual subset of innate immune cells that express a
surface receptor generated by somatic DNA rearrangement, a hallmark of cells of the …

T cells reactive to lipids and restricted by major histocompatibility complex (MHC) class I-like
molecules represent more than 15% of all lymphocytes in human blood. This heterogeneous …

iNKT cells, CD1d dependent natural killer T cells are a unique population of T cells. The
capacity of iNKT cells to produce regulatory cytokines first provided an indication of their …