Adrenocortical masses are among the most common tumors in humans. However, only a
small proportion of these tumors cause endocrine diseases (such as primary …

Humans have two isozymes with 11β-hydroxylase activity that are respectively required for
cortisol and aldosterone synthesis. CYP11B1 (11β-hydroxylase) converts 11-deoxycortisol …

Background Increased secretion of growth hormone leads to gigantism in children and
acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly …

Familial hyperaldosteronism type II (FH-II) is caused by adrenocortical hyperplasia or
aldosteronoma or both and is frequently transmitted in an autosomal dominant fashion …

Multiple endocrine neoplasia type 1 (MEN 1) is associated with parathyroid,
enteropancreatic, pituitary, and other tumors. The MEN1 gene, a tumor suppressor, is …

Background—Aldosterone and angiotensin (Ang) II both may cause organ damage.
Circulating aldosterone is produced in the adrenals; however, local cardiac synthesis has …

The vitamin D receptor (VDR) is a member of the steroid hormone receptor superfamily of
ligand‐activated transcription factors. The VDR gene was previously mapped to human …

Recent publications indicate genetic variation in milk production traits on proximal BTA14,
which cannot be explained solely with genetic variation in the DGAT1 gene. To elucidate …

In this study, the synthesis and biological evaluation of heteroaryl-substituted
dihydronaphthalenes and indenes (1− 16) is described. The compounds were tested for …

CYP11B1 and the closely related CYP11B2 are involved in the production of adrenal steroid
hormones. Although in human their primary structure is 93% identical they are involved in …