Identification of RNA structures and their roles in RNA functions
The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …
greatly facilitated our ability to map and characterize different aspects of RNA structures …
Endogenous double-stranded RNA
S Sadeq, S Al-Hashimi, CM Cusack, A Werner - Non-coding RNA, 2021 - mdpi.com
The birth of long non-coding RNAs (lncRNAs) is closely associated with the presence and
activation of repetitive elements in the genome. The transcription of endogenous …
activation of repetitive elements in the genome. The transcription of endogenous …
Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration
R Zhao, S Huang, J Li, A Gu, M Fu, W Hua… - Journal of Cell …, 2024 - rupress.org
The double-stranded RNA-binding protein Staufen1 (STAU1) regulates a variety of
physiological and pathological events via mediating RNA metabolism. STAU1 …
physiological and pathological events via mediating RNA metabolism. STAU1 …
Dicer structure and function: conserved and evolving features
D Zapletal, K Kubicek, P Svoboda, R Stefl - EMBO reports, 2023 - embopress.org
RNase III Dicer produces small RNAs guiding sequence‐specific regulations, with important
biological roles in eukaryotes. Major Dicer‐dependent mechanisms are RNA interference …
biological roles in eukaryotes. Major Dicer‐dependent mechanisms are RNA interference …
Deep structural insights into RNA‐binding disordered protein regions
Recent efforts to identify RNA binding proteins in various organisms and cellular contexts
have yielded a large collection of proteins that are capable of RNA binding in the absence of …
have yielded a large collection of proteins that are capable of RNA binding in the absence of …
Dimerization of ADAR1 modulates site-specificity of RNA editing
A Mboukou, V Rajendra, S Messmer, TC Mandl… - Nature …, 2024 - nature.com
Adenosine-to-inosine editing is catalyzed by adenosine deaminases acting on RNA
(ADARs) in double-stranded RNA (dsRNA) regions. Although three ADARs exist in …
(ADARs) in double-stranded RNA (dsRNA) regions. Although three ADARs exist in …
A practical perspective on the roles of solution NMR spectroscopy in drug discovery
Q Li, CB Kang - Molecules, 2020 - mdpi.com
Solution nuclear magnetic resonance (NMR) spectroscopy is a powerful tool to study
structures and dynamics of biomolecules under physiological conditions. As there are …
structures and dynamics of biomolecules under physiological conditions. As there are …
The role of lncRNA binding to RNA‑binding proteins to regulate mRNA stability in cancer progression and drug resistance mechanisms
N Zhang, K Wen - Oncology Reports, 2024 - spandidos-publications.com
Cancer is a disease that poses a serious threat to human health, the occurrence and
development of which involves complex molecular mechanisms. Long non-coding RNAs …
development of which involves complex molecular mechanisms. Long non-coding RNAs …
Differential conformational dynamics in two type-A RNA-binding domains drive the double-stranded RNA recognition and binding
Trans-activation response (TAR) RNA-binding protein (TRBP) has emerged as a key player
in the RNA interference pathway, wherein it binds to different pre-microRNAs (miRNAs) and …
in the RNA interference pathway, wherein it binds to different pre-microRNAs (miRNAs) and …
Noncanonical formation of SNX5 gene-derived circular RNA regulates cancer growth
YT Chen, HJ Tsai, CH Kan, CP Ma, HW Chen… - Cell Death & …, 2024 - nature.com
Oral squamous cell carcinoma (OSCC) is a prevalent cancer worldwide, exhibiting unique
regional prevalence. Despite advancements in diagnostics and therapy, the 5-year survival …
regional prevalence. Despite advancements in diagnostics and therapy, the 5-year survival …