Twenty-five years of structural parvovirology

M Mietzsch, JJ Pénzes, M Agbandje-McKenna - Viruses, 2019 - mdpi.com
Parvoviruses, infecting vertebrates and invertebrates, are a family of single-stranded DNA
viruses with small, non-enveloped capsids with T= 1 icosahedral symmetry. A quarter of a …

Develo** oncolytic viruses for the treatment of cervical cancer

E Kalafati, E Drakopoulou, NP Anagnou, KI Pappa - Cells, 2023 - mdpi.com
Cervical cancer represents one of the most important malignancies among women
worldwide. Current therapeutic approaches for cervical cancer are reported not only to be …

A novel approach to exploring the dark genome and its application to map** of the vertebrate virus fossil record

D Blanco-Melo, MA Campbell, H Zhu, TPW Dennis… - Genome Biology, 2024 - Springer
Background Genomic regions that remain poorly understood, often referred to as the dark
genome, contain a variety of functionally relevant and biologically informative features …

The Complex Role of Infectious Agents in Human Cutaneous T-Cell Lymphoma Pathogenesis: From Candidate Etiological Factors to Potential Therapeutics

A Angelova, J Rommelaere, G Ungerechts - Pathogens, 2024 - mdpi.com
Cutaneous T-cell lymphoma (CTCL) is a devastating, potentially fatal T-lymphocyte
malignancy affecting the skin. Despite all efforts, the etiology of this disease remains …

Comparative analysis reveals the long-term coevolutionary history of parvoviruses and vertebrates

MA Campbell, S Loncar, RM Kotin, RJ Gifford - PLoS Biology, 2022 - journals.plos.org
Parvoviruses (family Parvoviridae) are small DNA viruses that cause numerous diseases of
medical, veterinary, and agricultural significance and have important applications in gene …

The controversy of SARS‐CoV‐2 integration into the human genome

L AL‐Eitan, A Mihyar - Reviews in Medical Virology, 2024 - Wiley Online Library
Bat borne disease have attracted many researchers for years. The ability of the bat to host
several exogenous viruses has been a focal point in research lately. The latest pandemic …

Evolution of dependoparvoviruses across geological timescales—implications for design of AAV-based gene therapy vectors

E Hildebrandt, JJ Penzes, RJ Gifford… - Virus …, 2020 - academic.oup.com
Endogenous viral elements (EVEs) are genetic remnants of viruses that have integrated into
host genomes millions of years ago and retained as heritable elements passed on to …

The Structures and Functions of Parvovirus Capsids and Missing Pieces: the Viral DNA and Its Packaging, Asymmetrical Features, Nonprotein Components, and …

RA López-Astacio, OF Adu, H Lee… - Journal of …, 2023 - Am Soc Microbiol
Parvoviruses are among the smallest and superficially simplest animal viruses, infecting a
broad range of hosts, including humans, and causing some deadly infections. In 1990, the …

Development of evolutionarily conserved viral integration sites as safe harbors for human gene therapy

MA Quezada-Ramírez, S Loncar, MA Campbell… - bioRxiv, 2023 - biorxiv.org
Gene transfer into CD34+ hematopoietic stem and progenitor cells (HSPCs) involving
integrating viral vectors has unpredictable outcomes including potential adverse events like …

[HTML][HTML] Viral phrenology

DP Wilson, DA Roof - Viruses, 2021 - mdpi.com
We introduce Viral Phrenology, a new scheme for understanding the genomic composition
of spherical viruses based on the locations of their structural protrusions. We used …