The antitumor efficiency and clinical translation of traditional nanomedicines is mainly
restricted by low drug loading, complex preparation technology, and potential toxicity …

The last decade witnessed the great advances in the development of nanomedicines. As a
kind of attractive nanomedicine, carrier-free nanomedicines received extensive …

Covalent modification of therapeutic compounds is a clinically proven strategy to devise
prodrugs with enhanced treatment efficacies. This prodrug strategy relies on the modified …

Lipid–drug conjugates (LDCs) are drug molecules that have been covalently modified with
lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes …

Background Leishmaniasis is a destructive protozoan parasitic and vector-borne infection
characterized as a neglected tropical disease (NTD) that is currently endemic in more than …

The convergence of nanoscience and drug delivery has prompted the formation of the field
of nanomedicine, one that exploits the novel physicochemical and biological properties of …

Leishmaniasis is a vector-borne zoonotic disease caused by protozoan parasites of the
genus Leishmania, which are responsible for numerous clinical manifestations, such as …

We synthesized and characterized curcumin-coated gold nanoparticles (Cur@ AuNPs) and
investigated their stability, cytotoxicity, leishmanicidal activity in in vitro and in in vivo …

Leishmaniasis chemotherapy remains very challenging due to high cost of the drug and its
associated toxicity and drug resistance, which develops over a period of time. Combination …

Three new monoterpene indole alkaloids (1–3) have been isolated from the bark of
Geissospermum laeve, together with the known alkaloids (−)-leuconolam (4) …