Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially
perform in-depth assessments of adaptive immune cells that inform on understanding …

B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Antibodies have the capacity to bind a diverse set of antigens, and they have become critical
therapeutics and diagnostic molecules. The binding of antibodies is facilitated by a set of six …

Pan-betacoronavirus neutralizing antibodies may hold the key to develo** broadly
protective vaccines against novel pandemic coronaviruses and to more effectively respond …

Antibodies are key proteins of the adaptive immune system, and there exists a large body of
academic literature and patents dedicated to their study and concomitant conversion into …

Motivation The versatile binding properties of antibodies have made them an extremely
important class of biotherapeutics. However, therapeutic antibody development is a …

Existing antibody language models are limited by their use of unpaired antibody sequence
data. A recently published dataset of∼ 1.6× 10 6 natively paired human antibody sequences …

Therapeutic antibody engineering seeks to identify antibody sequences with specific binding
to a target and optimized drug-like properties. When guided by deep learning, antibody …

Highlights•Functional screens integrate with single cell BCR-sequencing and
transcriptomics.•Bottom-up and top-down MS enable comprehensive profiling of circulating …

Antibodies with lambda light chains (λ-antibodies) are generally considered to be less
developable than those with kappa light chains (κ-antibodies). Though this hypothesis has …