Catalytically Active Snake Venom PLA2 Enzymes: An Overview of Its Elusive Mechanisms of Reaction: Miniperspective

J Castro-Amorim, A Novo de Oliveira… - Journal of Medicinal …, 2023‏ - ACS Publications
Snake venom-secreted phospholipase A2 (svPLA2) enzymes, both catalytically active and
inactive, are a central component in envenoming. These are responsible for disrupting the …

Phospholipases A2: unveiling the secrets of a functionally versatile group of snake venom toxins

JM Gutiérrez, B Lomonte - Toxicon, 2013‏ - Elsevier
Phospholipases A2 (PLA2s) are abundant components of snake venoms, where they play
toxic and digestive roles. Despite having a similar three-dimensional structure, venom …

[كتاب][B] Handbook of venoms and toxins of reptiles

SP Mackessy - 2016‏ - taylorfrancis.com
The Handbook of Venoms and Toxins of Reptiles offers" one-stop shop**" to all biologists,
biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed …

Phospholipase A2 myotoxins from Bothrops snake venoms

JM Gutiérrez, B Lomonte - Toxicon, 1995‏ - Elsevier
Several myotoxins have been isolated from Bothrops snake venoms during the last 10
years. All of them are group II basic phospholipases A2, although some lack enzymatic …

Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: A comprehensive review

B Lomonte - Toxicon, 2023‏ - Elsevier
Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Phospholipase A2—a structural review

RK Arni, RJ Ward - Toxicon, 1996‏ - Elsevier
Phospholipases A2 (PLA2) are widely distributed in nature and are well characterized
proteins with respect to their catalytic and pharmacological activities. A wealth of structural …

Ophidian envenomation strategies and the role of purines

SD Aird - Toxicon, 2002‏ - Elsevier
Snake envenomation employs three well integrated strategies: prey immobilization via
hypotension, prey immobilization via paralysis, and prey digestion. Purines (adenosine …

An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action

B Lomonte, Y Angulo, L Calderón - Toxicon, 2003‏ - Elsevier
In 1984, the first venom phospholipase A2 (PLA2) with a lysine substituting for the highly
conserved aspartate 49 was discovered, in the North American crotalid snake Agkistrodon p …

Snake venom cytotoxins, phospholipase A2s, and Zn2+-dependent metalloproteinases: mechanisms of action and pharmacological relevance

SE Gasanov, RK Dagda… - Journal of clinical …, 2014‏ - pmc.ncbi.nlm.nih.gov
Snake venom toxins are responsible for causing severe pathology and toxicity following
envenomation including necrosis, apoptosis, neurotoxicity, myotoxicity, cardiotoxicity …

Snake venom Lys49 myotoxins: from phospholipases A2 to non-enzymatic membrane disruptors

B Lomonte, J Rangel - Toxicon, 2012‏ - Elsevier
Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers,
referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s) …