Specificity, versatility, and control of TGF-β family signaling
R Derynck, EH Budi - Science signaling, 2019 - science.org
Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
TGF-β family signaling in Drosophila
A Upadhyay, L Moss-Taylor, MJ Kim… - Cold Spring …, 2017 - cshperspectives.cshlp.org
The transforming growth factor β (TGF-β) family signaling pathway is conserved and
ubiquitous in animals. In Drosophila, fewer representatives of each signaling component are …
ubiquitous in animals. In Drosophila, fewer representatives of each signaling component are …
[HTML][HTML] Regulation of TGFβ and related signals by precursor processing
DB Constam - Seminars in cell & developmental biology, 2014 - Elsevier
Secreted cytokines of the TGFβ family are found in all multicellular organisms and implicated
in regulating fundamental cell behaviors such as proliferation, differentiation, migration and …
in regulating fundamental cell behaviors such as proliferation, differentiation, migration and …
Bone morphogenetic protein signaling: the pathway and its regulation
In the mid-1960s, bone morphogenetic proteins (BMPs) were first identified in the extracts of
bone to have the remarkable ability to induce heterotopic bone. When the Drosophila gene …
bone to have the remarkable ability to induce heterotopic bone. When the Drosophila gene …
BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis
BMP7/BMP2 or BMP7/BMP4 heterodimers are more active than homodimers in vitro, but it is
not known whether these heterodimers signal in vivo. To test this, we generated knock in …
not known whether these heterodimers signal in vivo. To test this, we generated knock in …
Multistep molecular mechanism for Bone morphogenetic protein extracellular transport in the Drosophila embryo
A Sawala, C Sutcliffe, HL Ashe - Proceedings of the …, 2012 - National Acad Sciences
In the Drosophila embryo, formation of a bone morphogenetic protein (BMP) morphogen
gradient requires transport of a heterodimer of the BMPs Decapentaplegic (Dpp) and Screw …
gradient requires transport of a heterodimer of the BMPs Decapentaplegic (Dpp) and Screw …
Strategies for exploring TGF-β signaling in Drosophila
AJ Peterson, MB O'Connor - Methods, 2014 - Elsevier
The TGF-β pathway is an evolutionarily conserved signal transduction module that mediates
diverse biological processes in animals. In Drosophila, both the BMP and Activin branches …
diverse biological processes in animals. In Drosophila, both the BMP and Activin branches …
[HTML][HTML] Peptidomics and processing of regulatory peptides in the fruit fly Drosophila
More than a decade has passed since the release of the Drosophila melanogaster genome
and the first predictions of fruit fly regulatory peptides (neuropeptides and peptide …
and the first predictions of fruit fly regulatory peptides (neuropeptides and peptide …
Morphogen transport: theoretical and experimental controversies
According to morphogen gradient theory, extracellular ligands produced from a localized
source convey positional information to receiving cells by signaling in a concentration …
source convey positional information to receiving cells by signaling in a concentration …
Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina
Drosophila color vision is achieved by comparing outputs from two types of color-sensitive
photoreceptors, R7 and R8. Ommatidia (unit eyes) are classified into two subtypes, known …
photoreceptors, R7 and R8. Ommatidia (unit eyes) are classified into two subtypes, known …