Toll-like receptor 4 (TLR4)/opioid receptor pathway crosstalk and impact on opioid analgesia, immune function, and gastrointestinal motility
P Zhang, M Yang, C Chen, L Liu, X Wei… - Frontiers in …, 2020 - frontiersin.org
Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns
(PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the …
(PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the …
Mas-related G protein–coupled receptor X2 and its activators in dermatologic allergies
H Kühn, P Kolkhir, M Babina, M Düll… - Journal of Allergy and …, 2021 - Elsevier
The Mas-related G protein–coupled receptor X2 (MRGPRX2) is a multiligand receptor
responding to various exogenous and endogenous stimuli. Being highly expressed on skin …
responding to various exogenous and endogenous stimuli. Being highly expressed on skin …
A potential role for the gut microbiome in substance use disorders
Pathological substance use disorders represent a major public health crisis with limited
effective treatment options. While much work has been done to understand the neuronal …
effective treatment options. While much work has been done to understand the neuronal …
Opioid drug abuse and modulation of immune function: consequences in the susceptibility to opportunistic infections
Infection rate among intravenous drug users (IDU) is higher than the general public, and is
the major cause of morbidity and hospitalization in the IDU population. Epidemiologic …
the major cause of morbidity and hospitalization in the IDU population. Epidemiologic …
Influence of opioids on immune function in patients with cancer pain: from bench to bedside
In patients with cancer, opioids are principally used for the management of acute surgical
and chronic cancer‐related pain. However, opioids have many non‐analgesic effects …
and chronic cancer‐related pain. However, opioids have many non‐analgesic effects …
Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives
Opioid receptors are widely distributed in the human body and are crucially involved in
numerous physiological processes. These include pain signaling in the central and the …
numerous physiological processes. These include pain signaling in the central and the …
Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner
Opiates are among the most prescribed drugs for pain management. However, morphine
use or abuse results in significant gut bacterial translocation and predisposes patients to …
use or abuse results in significant gut bacterial translocation and predisposes patients to …
The shift of an intestinal “microbiome” to a “pathobiome” governs the course and outcome of sepsis following surgical injury
MA Krezalek, J DeFazio, O Zaborina, A Zaborin… - Shock, 2016 - journals.lww.com
Sepsis following surgical injury remains a growing and worrisome problem following both
emergent and elective surgery. Although early resuscitation efforts and prompt antibiotic …
emergent and elective surgery. Although early resuscitation efforts and prompt antibiotic …
The effect of opioids on gastrointestinal function in the ICU
Y Yan, Y Chen, X Zhang - Critical care, 2021 - Springer
Gastrointestinal (GI) dysfunction is common in the critical care setting and is highly
associated with clinical outcomes. Opioids increase the risk for GI dysfunction and are …
associated with clinical outcomes. Opioids increase the risk for GI dysfunction and are …
Gut microbiome, surgical complications and probiotics
G Stavrou, K Kotzampassi - Annals of Gastroenterology …, 2016 - pmc.ncbi.nlm.nih.gov
The trigger for infectious complications in patients following major abdominal operations is
classically attributed to endogenous enteral bacterial translocation, due to the critical …
classically attributed to endogenous enteral bacterial translocation, due to the critical …