Targeting PI3K/Akt/mTOR in AML: rationale and clinical evidence
S Darici, H Alkhaldi, G Horne, HG Jørgensen… - Journal of Clinical …, 2020 - mdpi.com
Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy
characterized by excessive proliferation and accumulation of immature myeloid blasts in the …
characterized by excessive proliferation and accumulation of immature myeloid blasts in the …
[HTML][HTML] The role of autophagy in resistance to targeted therapies
Autophagy is a self-degradative cellular process, involved in stress response such as
starvation, hypoxia, and oxidative stress. This mechanism balances macro-molecule …
starvation, hypoxia, and oxidative stress. This mechanism balances macro-molecule …
A GSTP1-mediated lactic acid signaling promotes tumorigenesis through the PPP oxidative branch
Lactic acidosis is a feature of solid tumors and plays fundamental role (s) rendering cancer
cells to adapt to diverse metabolic stresses, but the mechanism underlying its roles in redox …
cells to adapt to diverse metabolic stresses, but the mechanism underlying its roles in redox …
Combating TKI resistance in CML by inhibiting the PI3K/Akt/mTOR pathway in combination with TKIs: A review
Chronic myeloid leukemia (CML), a myeloproliferative hematopoietic cancer, is caused by a
genetic translocation between chromosomes 9 and 22. This translocation produces a small …
genetic translocation between chromosomes 9 and 22. This translocation produces a small …
Mechanisms of resistance and implications for treatment strategies in chronic myeloid leukaemia
Simple Summary Chronic myeloid leukaemia (CML) is a type of blood cancer that is
currently well-managed with drugs that target cancer-causing proteins. However, a …
currently well-managed with drugs that target cancer-causing proteins. However, a …
Utilizing stimulated Raman scattering microscopy to study intracellular distribution of label-free ponatinib in live cells
K Sepp, M Lee, MTJ Bluntzer… - Journal of medicinal …, 2019 - ACS Publications
Stimulated Raman scattering (SRS) microscopy represents a powerful method for imaging
label-free drug distribution with high resolution. SRS was applied to image label-free …
label-free drug distribution with high resolution. SRS was applied to image label-free …
Understanding the role of autophagy in cancer formation and progression is a real opportunity to treat and cure human cancers
Simple Summary The modulation of autophagy represents a potential therapeutic strategy
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …
Regulation of beclin 1-mediated autophagy by oncogenic tyrosine kinases
Beclin 1 is a major regulator of autophagy, and it is a core component of the class III PI3K
complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number …
complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number …
A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with …
GA Horne, J Stobo, C Kelly, A Mukhopadhyay, AL Latif… - Leukemia, 2020 - nature.com
In chronic-phase chronic myeloid leukaemia (CP-CML), residual BCR-ABL1+ leukaemia
stem cells are responsible for disease persistence despite TKI. Based on in vitro data …
stem cells are responsible for disease persistence despite TKI. Based on in vitro data …
The role of exosomal microRNA in cancer drug resistance
Q Guo, H Wang, Y Yan, Y Liu, C Su, H Chen… - Frontiers in …, 2020 - frontiersin.org
Exosomes affect the initiation and progression of cancers. In the tumor microenvironment,
not only cancer cells, but also fibroblasts and immunocytes secrete exosomes. Exosomes …
not only cancer cells, but also fibroblasts and immunocytes secrete exosomes. Exosomes …