Hydrogels as drug delivery systems: A review of current characterization and evaluation techniques

M Vigata, C Meinert, DW Hutmacher, N Bock - Pharmaceutics, 2020 - mdpi.com
Owing to their tunable properties, controllable degradation, and ability to protect labile
drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a …

Photocrosslinked methacrylated natural macromolecular hydrogels for tissue engineering: A review

X Yang, X Li, Z Wu, L Cao - International Journal of Biological …, 2023 - Elsevier
A hydrogel is a three-dimensional (3D) network structure formed through polymer
crosslinking, and these have emerged as a popular research topic in recent years. Hydrogel …

Biomedical application of photo-crosslinked gelatin hydrogels

L **ang, W Cui - Journal of Leather Science and Engineering, 2021 - Springer
During the past decades, photo-crosslinked gelatin hydrogel (methacrylated gelatin, GelMA)
has gained a lot of attention due to its remarkable application in the biomedical field. It has …

Innovative transdermal drug delivery system based on amoxicillin-loaded gelatin methacryloyl microneedles obtained by 3D printing

H Erkus, T Bedir, E Kaya, GB Tinaz, O Gunduz… - Materialia, 2023 - Elsevier
The microneedle (MN) technology platform has a significant potential for enhancing the
efficacy of transdermal drug delivery, by using micron-scale arrays with restricted geometries …

An in vitro and ex vivo analysis of the potential of GelMA hydrogels as a therapeutic platform for preclinical spinal cord injury

CM Walsh, JK Wychowaniec, L Costello… - Advanced …, 2023 - Wiley Online Library
Spinal cord injury (SCI) is a devastating condition with no curative therapy currently
available. Immunomodulation can be applied as a therapeutic strategy to drive alternative …

Development of gelatin methacrylate (GelMa) hydrogels for versatile intracavitary applications

NS Kulkarni, G Chauhan, M Goyal, S Sarvepalli… - Biomaterials …, 2022 - pubs.rsc.org
Applicability of hydrogels as drug delivery systems is on the rise due to their highly tunable
degree of polymeric crosslinking to attain varying rates of payload release. Sustaining the …

A versatile GelMA composite hydrogel: Designing principles, delivery forms and biomedical applications

Y Zhang, J Lv, J Zhao, G Ling, P Zhang - European Polymer Journal, 2023 - Elsevier
Gelatin methacryloyl (GelMA), a kind of modified biomaterials with adjustable degradability
from gelatin, can composite with various composite materials and therapeutic substances …

Sustained released of bioactive mesenchymal stromal cell‐derived extracellular vesicles from 3D‐printed gelatin methacrylate hydrogels

LJ Born, ST McLoughlin, D Dutta… - … Research Part A, 2022 - Wiley Online Library
Extracellular vesicles (EVs) represent an emerging class of therapeutics with significant
potential and broad applicability. However, a general limitation is their rapid clearance after …

Preparation and characterization of 3D bioprinted gelatin methacrylate hydrogel incorporated with curcumin loaded chitosan nanoparticles for in vivo wound healing …

K Khoshmaram, F Yazdian, Z Pazhouhnia… - Biomaterials …, 2024 - Elsevier
This study developed a biomimetic composite bioink consisting of gelatin methacrylate
(GelMA)/chitosan nanoparticles (CSNPs) for extrusion-based 3D bioprinting. Additionally …

GelMA, click-chemistry gelatin and bioprinted polyethylene glycol-based hydrogels as 3D ex vivo drug testing platforms for patient-derived breast Cancer Organoids

N Bock, F Forouz, L Hipwood, J Clegg, P Jeffery… - Pharmaceutics, 2023 - mdpi.com
3D organoid model technologies have led to the development of innovative tools for cancer
precision medicine. Yet, the gold standard culture system (Matrigel®) lacks the ability for …