Multipronged diagnostic and therapeutic strategies for Alzheimer's disease

M Ramesh, T Govindaraju - Chemical science, 2022 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …

Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998–2018)

P Mishra, A Kumar, G Panda - Bioorganic & Medicinal Chemistry, 2019 - Elsevier
Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

Moringa oleifera alleviates homocysteine-induced Alzheimer's disease-like pathology and cognitive impairments

YAR Mahaman, F Huang, M Wu… - Journal of …, 2018 - content.iospress.com
Alzheimer's disease (AD) is multifactorial with unclear etiopathology. Due to the complexity
of AD, many attempted single therapy treatments, like Aß immunization, have generally …

Tacrine-based hybrids: past, present, and future

A Bubley, A Erofeev, P Gorelkin… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder which is characterized by β-
amyloid (Aβ) aggregation, τ-hyperphosphorylation, and loss of cholinergic neurons. The …

[HTML][HTML] Direct activation of protein phosphatase 2A (PP2A) by tricyclic sulfonamides ameliorates Alzheimer's disease pathogenesis in cell and animal models

H Wei, H Zhang, X Wang, J **e, D An, L Wan, J Wang… - …, 2020 - Elsevier
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease for which there are
limited therapeutic strategies. Protein phosphatase 2A (PP2A) activity is decreased in AD …

Multitarget directed ligand approaches for Alzheimer's disease: A Comprehensive Review

N Ramalakshmi, R RS, N CN - Mini Reviews in Medicinal …, 2021 - ingentaconnect.com
Background: Alzheimer's disease (AD) is a multifactorial neurodegenerative disease, and a
drug which targets a single protein would not provide a cure for this disease. Currently …

[HTML][HTML] A network pharmacology approach to uncover the key ingredients in Ginkgo Folium and their anti-Alzheimer's disease mechanisms

P Zeng, M Fang, H Zhao, J Guo - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
This study aimed to identify potential anti-Alzheimer's disease (AD) targets and action
mechanisms of Ginkgo Folium (GF) through a network pharmacology approach. Eighty-four …

Schisantherin B ameliorates Aβ1–42-induced cognitive decline via restoration of GLT-1 in a mouse model of Alzheimer's disease

M Xu, Y Dong, S Wan, T Yan, J Cao, L Wu, K Bi… - Physiology & …, 2016 - Elsevier
Accumulation of amyloid beta (Aβ) peptide and hyperphosphorylated tau protein has been
proposed to play roles in neural destruction which induce Alzheimer's disease (AD) …

A review of the mechanisms underlying selected comorbidities in Alzheimer's disease

K Maciejewska, K Czarnecka, P Szymański - Pharmacological Reports, 2021 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central
nervous system (CNS) leading to mental deterioration and devastation, and eventually a …

[HTML][HTML] Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats

MTM Salissou, YAR Mahaman, F Zhu, F Huang… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
Although few drugs are available today for the management of Alzheimer's disease (AD)
and many plants and their extracts are extensively employed in animals' studies and AD …