Preclinical models of epithelial ovarian cancer: practical considerations and challenges for a meaningful application
A Ciucci, M Buttarelli, A Fagotti, G Scambia… - Cellular and Molecular …, 2022 - Springer
Despite many improvements in ovarian cancer diagnosis and treatment, until now,
conventional chemotherapy and new biological drugs have not been shown to cure the …
conventional chemotherapy and new biological drugs have not been shown to cure the …
Current status and prospects of clinical treatment of osteosarcoma
ZY Jiang, JB Liu, XF Wang, YS Ma… - Technology in cancer …, 2022 - journals.sagepub.com
Osteosarcoma, one of the common malignant tumors in the skeletal system, originates in
mesenchymal tissue, and the most susceptible area of occurrence is the metaphysis with its …
mesenchymal tissue, and the most susceptible area of occurrence is the metaphysis with its …
Application of PARP inhibitors combined with immune checkpoint inhibitors in ovarian cancer
F **ao, ZB Wang, L Qiao, X Zhang, NYY Wu… - Journal of Translational …, 2024 - Springer
The advent of polyadenosine diphosphate ribose polymerase inhibitors (PARPi) has
brought about significant changes in the field of ovarian cancer treatment. However, in 2022 …
brought about significant changes in the field of ovarian cancer treatment. However, in 2022 …
Dual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids
E Cesari, A Ciucci, M Pieraccioli, C Caggiano… - Journal of Experimental …, 2023 - Springer
Background High grade serous ovarian cancer (HGSOC) is highly lethal, partly due to
chemotherapy resistance and limited availability of targeted approaches. Cyclin dependent …
chemotherapy resistance and limited availability of targeted approaches. Cyclin dependent …
The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer
I Masi, F Ottavi, D Del Rio, V Caprara, C Vastarelli… - Cell Death & …, 2023 - nature.com
Dissemination of high-grade serous ovarian cancer (HG-SOC) in the omentum and
intercalation into a mesothelial cell (MC) monolayer depends on functional α5β1 integrin …
intercalation into a mesothelial cell (MC) monolayer depends on functional α5β1 integrin …
[HTML][HTML] Predictive value of machine learning for platinum chemotherapy responses in ovarian cancer: systematic review and meta-analysis
Q Wang, Z Chang, X Liu, Y Wang, C Feng… - Journal of Medical …, 2024 - jmir.org
Background Machine learning is a potentially effective method for predicting the response to
platinum-based treatment for ovarian cancer. However, the predictive performance of …
platinum-based treatment for ovarian cancer. However, the predictive performance of …
Oligopeptide/histidine transporter PHT1 and PHT2—function, regulation, and pathophysiological implications specifically in immunoregulation
M Dong, P Li, J Luo, B Chen, H Jiang - Pharmaceutical Research, 2023 - Springer
The oligopeptide/histidine transporters PHT1 and PHT2, two mammalian solute carrier
family 15A proteins, mediate the transmembrane transport of histidine and some …
family 15A proteins, mediate the transmembrane transport of histidine and some …
Multi-omics data analysis identifies prognostic biomarkers across cancers
Combining omics data from different layers using integrative methods provides a better
understanding of the biology of a complex disease such as cancer. The discovery of …
understanding of the biology of a complex disease such as cancer. The discovery of …
[HTML][HTML] Targeting PLCG2 suppresses tumor progression, orchestrates the tumor immune microenvironment and potentiates immune checkpoint blockade therapy for …
X Zhou, J Lin, Y Shao, H Zheng, Y Yang… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Background: Tumor progression and limited benefits of immune checkpoint blockade (ICB)
therapy have been two major challenges in the clinical management of colorectal cancer …
therapy have been two major challenges in the clinical management of colorectal cancer …
Integrated single-cell and transcriptome sequencing analyses determines a chromatin regulator-based signature for evaluating prognosis in lung adenocarcinoma
Q Shi, S Han, X Liu, S Wang, H Ma - Frontiers in oncology, 2022 - frontiersin.org
Background Accumulating evidence has highlighted the significance of chromatin regulator
(CR) in pathogenesis and progression of cancer. However, the prognostic role of CRs in …
(CR) in pathogenesis and progression of cancer. However, the prognostic role of CRs in …