Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: a systematic review, meta-analysis, and meta-regression

AX Garg, RS Suri, N Barrowman, F Rehman, D Matsell… - Jama, 2003 - jamanetwork.com
ContextThe long-term renal prognosis of patients with diarrhea-associated hemolytic uremic
syndrome (HUS) remains controversial. ObjectivesTo quantify the long-term renal prognosis …

Aetiology and pathogenesis of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome: the role of von Willebrand factor-cleaving protease

M Furlan, B Lämmle - Best practice & research Clinical haematology, 2001 - Elsevier
Thrombotic thrombocytopenic purpura (TTP) and haemolytic uraemic syndrome (HUS) are
today often regarded as variants of one syndrome denoted as TTP/HUS, characterized by …

[HTML][HTML] Shiga toxin/lipopolysaccharide activates caspase-4 and gasdermin D to trigger mitochondrial reactive oxygen species upstream of the NLRP3 inflammasome

JM Platnich, H Chung, A Lau, CF Sandall… - Cell reports, 2018 - cell.com
The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by
intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways …

A murine model of HUS: Shiga toxin with lipopolysaccharide mimics the renal damage and physiologic response of human disease

TR Keepers, MA Psotka, LK Gross… - Journal of the American …, 2006 - journals.lww.com
Hemolytic uremic syndrome (HUS), which is caused by Shiga toxin–producing Escherichia
coli infection, is the leading cause of acute renal failure in children. At present, there is no …

Pathogenesis of Shiga toxin-induced hemolytic uremic syndrome

PE Ray, XH Liu - Pediatric Nephrology, 2001 - Springer
The term hemolytic uremic syndrome (HUS) was first introduced to describe a
heterogeneous group of diseases characterized by microangiopathic hemolytic anemia …

A Novel Escherichia coli O157:H7 Clone Causing a Major Hemolytic Uremic Syndrome Outbreak in China

Y **ong, P Wang, R Lan, C Ye, H Wang, J Ren, H **g… - PloS one, 2012 - journals.plos.org
An Escherichia coli O157: H7 outbreak in China in 1999 caused 177 deaths due to
hemolytic uremic syndrome. Sixteen outbreak associated isolates were found to belong to a …

A novel murine infection model for Shiga toxin–producing Escherichia coli

EM Mallick, ME McBee, VK Vanguri… - The Journal of …, 2012 - Am Soc Clin Investig
Enterohemorrhagic E. coli (EHEC) is an important subset of Shiga toxin–producing (Stx-
producing) E. coli (STEC), pathogens that have been implicated in outbreaks of food-borne …

Enterohemorrhagic Escherichia coli Pathogenesis and the Host Response

D Karpman, A Ståhl - … Escherichia coli and Other Shiga Toxin …, 2015 - Wiley Online Library
Bacterial exotoxins may cause damage to host cells by defined mechanisms. Depending on
the presence of the globotriaosylceramide (Gb3) receptor, Shiga toxin may bind to cells and …

Shiga toxin 2 targets the murine renal collecting duct epithelium

MA Psotka, F Obata, GL Kolling, LK Gross… - Infection and …, 2009 - Am Soc Microbiol
Hemolytic-uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli
infection is a leading cause of pediatric acute renal failure. Bacterial toxins produced in the …

Is haem the real target of COVID-19?

V Rapozzi, A Juarranz, A Habib, A Ihan… - … and photodynamic therapy, 2021 - Elsevier
Although a vaccination campaign has been launched in many countries, the COVID-19
pandemic is not under control. The main concern is the emergence of new variants of SARS …