Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that can lead to clinical
manifestations of systemic diseases. Its leading features include chronic synovial …

Background Lung diseases including chronic obstructive pulmonary disease (COPD),
infections like influenza, acute respiratory distress syndrome (ARDS), asthma and …

Synovial proliferation, neovascularization and leukocyte extravasation transform the
normally acellular synovium into an invasive tumour-like'pannus'. The highly dysregulated …

Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical,
emotional and socioeconomic consequences. Despite advances in targeted biologic and …

STAT3 activation has been observed in several autoimmune diseases, suggesting that
STAT3-mediated pathways promote pathologic immune responses. We provide in vivo …

Effector T cell responses can be modulated by competing positive or negative signals
transduced by natural killer (NK) cell receptors. This raises the possibility that dominant T …

Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes irreversible joint
damage and significant disability. However, the fundamental mechanisms underlying how …

Self-help by means of dietary interventions can help in management of various disorders
including rheumatoid arthritis (RA), a debilitating autoimmune disease. Dietary interventions …

Appropriate regulation of B cell differentiation into plasma cells is essential for humoral
immunity while preventing antibody-mediated autoimmunity; however, the underlying …

It has been suggested that interleukin-6 (IL-6) plays a key role in the pathogenesis of
rheumatoid arthritis (RA), including osteoporosis not only in inflamed joints but also in the …