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Optogenetics for light control of biological systems
Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …
Probing neural codes with two-photon holographic optogenetics
Optogenetics ushered in a revolution in how neuroscientists interrogate brain function.
Because of technical limitations, the majority of optogenetic studies have used low spatial …
Because of technical limitations, the majority of optogenetic studies have used low spatial …
[HTML][HTML] Targeted activation of hippocampal place cells drives memory-guided spatial behavior
The hippocampus is crucial for spatial navigation and episodic memory formation.
Hippocampal place cells exhibit spatially selective activity within an environment and have …
Hippocampal place cells exhibit spatially selective activity within an environment and have …
Cortical layer–specific critical dynamics triggering perception
INTRODUCTION Perceptual experiences in mammals may arise from patterns of neural
circuit activity in cerebral cortex. For example, primary visual cortex (V1) is causally capable …
circuit activity in cerebral cortex. For example, primary visual cortex (V1) is causally capable …
Fluorescence imaging of large-scale neural ensemble dynamics
Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …
thousands of individual neurons, identified genetically or by their connectivity, across …
The influence of cortical activity on perception depends on behavioral state and sensory context
The mechanistic link between neural circuit activity and behavior remains unclear. While
manipulating cortical activity can bias certain behaviors and elicit artificial percepts, some …
manipulating cortical activity can bias certain behaviors and elicit artificial percepts, some …
DeepCGH: 3D computer-generated holography using deep learning
The goal of computer-generated holography (CGH) is to synthesize custom illumination
patterns by modulating a coherent light beam. CGH algorithms typically rely on iterative …
patterns by modulating a coherent light beam. CGH algorithms typically rely on iterative …
Cortico-cortical feedback engages active dendrites in visual cortex
Sensory processing in the neocortex requires both feedforward and feedback information
flow between cortical areas. In feedback processing, higher-level representations provide …
flow between cortical areas. In feedback processing, higher-level representations provide …
BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons
Optogenetic manipulation of neuronal activity through excitatory and inhibitory opsins has
become an indispensable experimental strategy in neuroscience research. For many …
become an indispensable experimental strategy in neuroscience research. For many …
Single-neuron perturbations reveal feature-specific competition in V1
The computations performed by local neural populations, such as a cortical layer, are
typically inferred from anatomical connectivity and observations of neural activity. Here we …
typically inferred from anatomical connectivity and observations of neural activity. Here we …