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Polo-like kinase 1 (PLK1) signaling in cancer and beyond
S Iliaki, R Beyaert, IS Afonina - Biochemical pharmacology, 2021 - Elsevier
PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy
K Strebhardt - Nature reviews Drug discovery, 2010 - nature.com
The polo-like kinase 1 (PLK1) acts in concert with cyclin-dependent kinase 1–cyclin B1 and
Aurora kinases to orchestrate a wide range of critical cell cycle events. Because PLK1 has …
Aurora kinases to orchestrate a wide range of critical cell cycle events. Because PLK1 has …
Polo-like kinases and the orchestration of cell division
Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis
and cytokinesis. In agreement with a broad range of proposed functions during cell division …
and cytokinesis. In agreement with a broad range of proposed functions during cell division …
Targeting polo-like kinase 1 for cancer therapy
K Strebhardt, A Ullrich - Nature reviews cancer, 2006 - nature.com
Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of
genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in …
genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in …
Plk4-induced centriole biogenesis in human cells
J Kleylein-Sohn, J Westendorf, M Le Clech… - Developmental cell, 2007 - cell.com
We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces
centrosome amplification through the simultaneous generation of multiple procentrioles …
centrosome amplification through the simultaneous generation of multiple procentrioles …
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.
HA Lane, EA Nigg - Journal of Cell Biology, 1996 - rupress.org
Mammalian polo-like kinase 1 (Plkl) is structurally related to the polo gene product of
Drosophila melanogaster, Cdc5p of Saccharomyces cerevisiae, and plol÷ of …
Drosophila melanogaster, Cdc5p of Saccharomyces cerevisiae, and plol÷ of …
Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication
KF Sonnen, AM Gabryjonczyk, E Anselm… - Journal of cell …, 2013 - journals.biologists.com
Summary Polo-like kinase 4 (Plk4) is a key regulator of centriole duplication, but the
mechanism underlying its recruitment to mammalian centrioles is not understood. In flies …
mechanism underlying its recruitment to mammalian centrioles is not understood. In flies …
From Plk1 to Plk5: functional evolution of polo-like kinases
Mammalian polo-like kinases (Plks) are characterized by the presence of an N-terminal
protein kinase domain and a C-terminal polo-box domain (PBD) involved in substrate …
protein kinase domain and a C-terminal polo-box domain (PBD) involved in substrate …