Marginal-zone lymphomas
D Rossi, F Bertoni, E Zucca - New England journal of medicine, 2022 - Mass Medical Soc
Marginal-Zone Lymphomas The third most common lymphoma, MZL is usually indolent and
often a consequence of chronic antigenic stimulation from a pathogen such as Helicobacter …
often a consequence of chronic antigenic stimulation from a pathogen such as Helicobacter …
Transcriptional regulation of memory B cell differentiation
BJ Laidlaw, JG Cyster - Nature Reviews Immunology, 2021 - nature.com
Memory B cells (MBCs) are critical for the rapid development of protective immunity
following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such …
following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such …
Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL
In diffuse large B cell lymphoma (DLBCL), tumors belonging to the ABC but not GCB gene
expression subgroup rely upon chronic active B cell receptor signaling for viability, a …
expression subgroup rely upon chronic active B cell receptor signaling for viability, a …
The genomic and transcriptional landscape of primary central nervous system lymphoma
Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …
[HTML][HTML] Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues
The capability to spatially explore RNA biology in formalin-fixed paraffin-embedded (FFPE)
tissues holds transformative potential for histopathology research. Here, we present …
tissues holds transformative potential for histopathology research. Here, we present …
Molecular profiling in diffuse large B‐cell lymphoma: why so many types of subtypes?
The term diffuse large B‐cell lymphoma (DLBCL) includes a heterogeneous collection of
biologically distinct tumours. This heterogeneity currently presents a barrier to the successful …
biologically distinct tumours. This heterogeneity currently presents a barrier to the successful …
ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis
ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …
HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non–small cell lung cancer
LJ Eichner, SD Curtis, SN Brun, CK McGuire… - Science …, 2023 - science.org
HDAC3 is one of the main targets of histone deacetylase (HDAC) inhibitors in clinical
development as cancer therapies, yet the in vivo role of HDAC3 in solid tumors is unknown …
development as cancer therapies, yet the in vivo role of HDAC3 in solid tumors is unknown …
BTG1 mutation yields supercompetitive B cells primed for malignant transformation
Multicellular life requires altruistic cooperation between cells. The adaptive immune system
is a notable exception, wherein germinal center B cells compete vigorously for limiting …
is a notable exception, wherein germinal center B cells compete vigorously for limiting …