Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced
by brain glucose hypometabolism that can be observed potentially decades prior to the …

Importance Converging evidence suggests that Alzheimer disease (AD) involves insulin
signaling impairment. Patients with AD and individuals at risk for AD show reduced glucose …

The epidemiological connection between diabetes, obesity, and dementia represents an
important public health challenge but also an opportunity to further understand these …

People with type 2 diabetes are at an increased risk of cognitive impairment and dementia
(including Alzheimer's disease), as well as subtle forms of cognitive dysfunction. Current …

Background The relationship between biomarkers of metabolic syndrome and insulin
resistance, plasma triglyceride/HDL cholesterol (TG/HDL-C) ratio, on the rate of cognitive …

A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …

Insulin is a peptide well known for its role in regulating glucose metabolism in peripheral
tissues. Emerging evidence from human and animal studies indicate the multifactorial role of …