Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling

RA Coleman, DG Mashek - Chemical reviews, 2011 - ACS Publications
Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …

[HTML][HTML] Triglyceride-rich lipoproteins and cytosolic lipid droplets in enterocytes: key players in intestinal physiology and metabolic disorders

S Demignot, F Beilstein, E Morel - Biochimie, 2014 - Elsevier
During the post-prandial phase, intestinal triglyceride-rich lipoproteins (TRL) ie chylomicrons
are the main contributors to the serum lipid level, which is linked to coronary artery diseases …

Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase

JG Granneman, HPH Moore, EP Mottillo, Z Zhu… - Journal of Biological …, 2011 - jbc.org
Members of the perilipin family of lipid droplet scaffold proteins are thought to play important
roles in tissue-specific regulation of triglyceride metabolism, but the mechanisms involved …

[HTML][HTML] Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI …

FPW Radner, IE Streith, G Schoiswohl… - Journal of Biological …, 2010 - Elsevier
Comparative gene identification-58 (CGI-58), also designated as α/β-hydrolase domain
containing-5 (ABHD-5), is a lipid droplet-associated protein that activates adipose …

CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance [S]

JM Brown, JL Betters, C Lord, Y Ma, X Han, K Yang… - Journal of lipid …, 2010 - jlr.org
Mutations of Comparative Gene Identification-58 (CGI-58) in humans cause triglyceride (TG)
accumulation in multiple tissues. Mice genetically lacking CGI-58 die shortly after birth due …

[PDF][PDF] Targeting β‐catenin in hepatocellular cancers induced by coexpression of mutant β‐catenin and K‐Ras in mice

J Tao, R Zhang, S Singh, M Poddar, E Xu… - …, 2017 - Wiley Online Library
Recently, we have shown that coexpression of hMet and mutant‐β‐catenin using slee**
beauty transposon/transposase leads to hepatocellular carcinoma (HCC) in mice that …

[PDF][PDF] TM6SF2 rs58542926 impacts lipid processing in liver and small intestine

EA O'Hare, R Yang, LM Yerges‐Armstrong… - …, 2017 - Wiley Online Library
The transmembrane 6 superfamily member 2 (TM6SF2) loss‐of‐function variant rs58542926
is a genetic risk factor for nonalcoholic fatty liver disease and progression to fibrosis but is …

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice

SM Turpin, AJ Hoy, RD Brown, C Garcia Rudaz… - Diabetologia, 2011 - Springer
Aims/hypothesis Hepatic steatosis is characterised by excessive triacylglycerol
accumulation and is strongly associated with insulin resistance. An inability to efficiently …

The proteome of cytosolic lipid droplets isolated from differentiated Caco‐2/TC7 enterocytes reveals cell‐specific characteristics

J Bouchoux, F Beilstein, T Pauquai… - Biology of the …, 2011 - Wiley Online Library
Background information. Intestinal absorption of alimentary lipids is a complex process
ensured by enterocytes and leading to TRL [TAG (triacylglycerol)‐rich lipoprotein] assembly …

[HTML][HTML] ABHD5—A regulator of lipid metabolism essential for diverse cellular functions

M Schratter, A Lass, FPW Radner - Metabolites, 2022 - mdpi.com
The α/β-Hydrolase domain-containing protein 5 (ABHD5; also known as comparative gene
identification-58, or CGI-58) is the causative gene of the Chanarin-Dorfman syndrome …