Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Cancer is a huge challenge for people worldwide. High reactive oxygen species (ROS)
levels are a recognized hallmark of cancer and an important aspect of cancer treatment …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Apoptosis is widely known as programmed cell death eliciting no inflammatory responses.
The intricacy of apoptosis has been a focus of an array of researches, accumulating a wealth …

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …

Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

Adenosine monophosphate–activated protein kinase (AMPK) activity is stimulated to
promote metabolic adaptation upon energy stress. However, sustained metabolic stress may …

Simple Summary Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)
plays an important role in apoptosis and tumor immunosurveillance. Because TRAIL …

The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …