[HTML][HTML] Microplastic burden in Africa: a review of occurrence, impacts, and sustainability potential of bioplastics

ES Okeke, OA Olagbaju, CO Okoye, CI Addey… - Chemical Engineering …, 2022 - Elsevier
Although the use of plastics varies across different regions, Africa is ranked second after
Asia as an indiscernible consumer of plastics that break down into microplastic. Moreover …

[HTML][HTML] Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease

MA Pappolla, G Perry, X Fang, M Zagorski… - Neurobiology of …, 2021 - Elsevier
Sporadic late-onset Alzheimer's disease (AD) is the most frequent cause of dementia
associated with aging. Due to the progressive aging of the population, AD is becoming a …

Perfluorooctane sulfonamide (PFOSA) induces cardiotoxicity via aryl hydrocarbon receptor activation in zebrafish

H Chen, W Qiu, X Yang, F Chen, J Chen… - … science & technology, 2022 - ACS Publications
Perfluorooctane sulfonamide (PFOSA), a precursor of perfluorooctanesulfonate (PFOS), is
widely used during industrial processes, though little is known about its toxicity, particularly …

Aryl hydrocarbon receptor: Its roles in physiology

Z Kou, W Dai - Biochemical pharmacology, 2021 - Elsevier
Aryl hydrocarbon receptor (AHR) was initially discovered as a cellular protein involved in
mediating the detoxification of xenobiotic compounds. Extensive research in the past two …

Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex

SH Seok, W Lee, L Jiang, K Molugu, A Zheng… - Proceedings of the …, 2017 - pnas.org
The aryl hydrocarbon receptor (AHR) belongs to the PAS (PER-ARNT-SIM) family
transcription factors and mediates broad responses to numerous environmental pollutants …

The aryl hydrocarbon receptor: a multifunctional chemical sensor for host defense and homeostatic maintenance

K Kawajiri, Y Fujii-Kuriyama - Experimental animals, 2017 - jstage.jst.go.jp
The aryl hydrocarbon receptor (AHR) is a pivotal chemical sensor that transduces extrinsic
and intrinsic signals into cellular responses. AHR was originally thought to be involved in not …

Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and …

G Anderson - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
The pathophysiological underpinnings of neuroprogressive processes in recurrent major
depressive disorder (rMDD) are reviewed. A wide array of biochemical processes underlie …

Canonical and non-canonical aryl hydrocarbon receptor signaling pathways

EJ Wright, KP De Castro, AD Joshi… - Current opinion in …, 2017 - Elsevier
Decades of research on the Aryl hydrocarbon Receptor (AhR) has unveiled its involvement
in the toxicity of halogenated and polycyclic aromatic hydrocarbons, and a myriad of normal …

The aryl hydrocarbon receptor (AhR) in the aging process: another puzzling role for this highly conserved transcription factor

V Brinkmann, N Ale-Agha, J Haendeler… - Frontiers in …, 2020 - frontiersin.org
Aging is the most important risk factor for the development of major life-threatening diseases
such as cardiovascular disorders, cancer, and neurodegenerative disorders. The aging …

AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos

H **, C Ji, F Ren, S Aniagu, J Tong, Y Jiang… - Journal of Hazardous …, 2020 - Elsevier
Trichloroethylene (TCE), a widely used chlorinated solvent, is a common environmental
pollutant. Current evidence shows that TCE could induce heart defects during embryonic …