Molecular structure and function of the glycine receptor chloride channel
JW Lynch - Physiological reviews, 2004 - journals.physiology.org
The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …
Native glycine receptor subtypes and their physiological roles
JW Lynch - Neuropharmacology, 2009 - Elsevier
The glycine receptor chloride channel (GlyR), a member of the pentameric Cys-loop ion
channel receptor family, mediates inhibitory neurotransmission in the spinal cord, brainstem …
channel receptor family, mediates inhibitory neurotransmission in the spinal cord, brainstem …
GABA and glycine as neurotransmitters: a brief history
NG Bowery, TG Smart - British journal of pharmacology, 2006 - Wiley Online Library
γ‐Aminobutyric acid (GABA) emerged as a potentially important brain chemical just over 50
years ago, but its significance as a neurotransmitter was not fully realized until over 16 years …
years ago, but its significance as a neurotransmitter was not fully realized until over 16 years …
Neurotransmitters as early signals for central nervous system development
During brain ontogenesis, the temporal and spatial generation of the different types of
neuronal and glial cells from precursors occurs as a sequence of successive progenitor …
neuronal and glial cells from precursors occurs as a sequence of successive progenitor …
Conformational transitions and allosteric modulation in a heteromeric glycine receptor
Abstract Glycine Receptors (GlyRs) provide inhibitory neuronal input in the spinal cord and
brainstem, which is critical for muscle coordination and sensory perception. Synaptic GlyRs …
brainstem, which is critical for muscle coordination and sensory perception. Synaptic GlyRs …
Single-channel behavior of heteromeric α1β glycine receptors: an attempt to detect a conformational change before the channel opens
The α1β heteromeric receptors are likely to be the predominant synaptic form of glycine
receptors in the adult. Their activation mechanism was investigated by fitting putative …
receptors in the adult. Their activation mechanism was investigated by fitting putative …
Glycine as a neurotransmitter in the forebrain: a short review
MS Hernandes, LRP Troncone - Journal of neural transmission, 2009 - Springer
Since the late 1970s glycine has been considered an important inhibitory neurotransmitter in
brain stem and medulla. The description of its involvement in the mechanism of action of the …
brain stem and medulla. The description of its involvement in the mechanism of action of the …
Molecular pharmacology of the glycine receptor chloride channel
The glycine receptor (GlyR) Cl-channel belongs to the cysteine-loop family of ligand-gated
ion channel receptors. It is best known for mediating inhibitory neurotransmission in motor …
ion channel receptors. It is best known for mediating inhibitory neurotransmission in motor …
RNA editing produces glycine receptor α3P185L, resulting in high agonist potency
The function of supramedullary glycine receptors (GlyRs) is still unclear. Using Wistar rat
collicular slices, we demonstrate GlyR-mediated inhibition of spike discharge elicited by low …
collicular slices, we demonstrate GlyR-mediated inhibition of spike discharge elicited by low …
Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
The development of neuropathic pain involves persistent changes in signalling within pain
pathways. Reduced inhibitory signalling in the spinal cord following nerve-injury has been …
pathways. Reduced inhibitory signalling in the spinal cord following nerve-injury has been …