Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

Behavior is tightly synchronized with bodily physiology. Internal needs from the body drive
behavior selection, while optimal behavior performance requires a coordinated …

Tumor innervation is a common phenomenon with unknown mechanism. Here, we
discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de …

Skin immunity is regulated by many mediator molecules. One is the neuropeptide calcitonin
gene-related peptide (CGRP). CGRP has roles in regulating the function of components of …

Bidirectional interplay between the peripheral immune and nervous systems plays a crucial
role in maintaining homeostasis and responding to noxious stimuli. This crosstalk is …

Rationale: Psoriasis is a chronic inflammatory disease caused by a complex interplay
between the immune and nervous systems with recurrent scaly skin plaques, thickened …

Recently, increasing numbers of studies have demonstrated that transient receptor potential
ankyrin 1 (TRPA1) can be used as a potential target for the treatment of inflammatory …

Psoriasis is a chronic inflammatory disease with a multifactorial origin that affects the skin. It
is characterized by keratinocyte hyperproliferation, which results in erythemato-squamous …

Pruritus is defined as an unpleasant sensation that elicits a desire to scratch. Nearly a third
of the world's population may suffer from pruritus during their lifetime. This symptom is widely …

Over the last decades, a great array of molecular mediators have been identified as potential
targets for the treatment of chronic pain. Among these mediators, transient receptor potential …