The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

tRNA biology has come of age, revealing an unprecedented level of understanding and
many unexpected discoveries along the way. This review highlights new findings on the …

Identification of components present in biological complexes requires their purification to
near homogeneity. Methods of purification vary from protein to protein, making it impossible …

Aneuploidy causes severe developmental defects and is a near universal feature of tumor
cells. Despite its profound effects, the cellular processes affected by aneuploidy are not well …

▪ Abstract The synthesis of ribosomes is one of the major metabolic pathways in all cells. In
addition to around 75 individual ribosomal proteins and 4 ribosomal RNAs, synthesis of a …

Transfer RNAs (tRNAs) are essential for protein synthesis. In eukaryotes, tRNA biosynthesis
employs a specialized RNA polymerase that generates initial transcripts that must be …

1Department of Biochemistry and Molecular Biology, Pennsylvania State University College
of Medicine, Hershey, Pennsylvania 17033, USA; 2Department of Biochemistry and …

Images of entire cells are preceding atomic structures of the separate molecular machines
that they contain. The resulting gap in knowledge can be partly bridged by protein-protein …

Nuclear ribonuclease (RNase) P is a ubiquitous essential ribonucleoprotein complex, one of
only two known RNA-based enzymes found in all three domains of life. The RNA component …

In eukaryotes, dozens of posttranscriptional modifications are directed to specific
nucleotides in ribosomal RNAs (rRNAs) by small nucleolar RNAs (snoRNAs). We identified …