Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

Simple Summary Microtubules (MTs) are dynamic structures that compose part of the cell
cytoskeleton. They play important roles in various cellular functions, such as intracellular …

Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …

Gene ontology analyses of high-confidence autism spectrum disorder (ASD) risk genes
highlight chromatin regulation and synaptic function as major contributors to pathobiology …

Histone methylations play a crucial role in the development of neuropathic pain, and SET
domain containing 2 (SETD2), a histone methyltransferase, serves as the sole tri-methylase …

Brain size is controlled by several factors during neuronal development, including neural
progenitor proliferation, neuronal arborization, gliogenesis, cell death, and synaptogenesis …

The covalent modification of histones is critical for many biological functions in mammals,
including gene regulation and chromatin structure. Posttranslational histone modifications …

Epigenetic dysregulation is an important contributor to carcinogenesis. This is not surprising,
as chromatin—genomic DNA organized around structural histone scaffolding—serves as the …

Introduction: Luscan-Lumish syndrome (LLS) is currently recognized as a rarely-observed
condition featured with overgrowth, macrocephaly, obesity, type I Chiari malformation, and …

Abstract Protein phosphatase 2A (PP2A) is a family of multifunctional enzymatic complexes
crucial for cellular signalling, playing a pivotal role in brain function and development …