The biological regulation of transcription factors (TFs) and repressor proteins is an important
mechanism for maintaining cell homeostasis. In B cell acute lymphoblastic leukemia (B-ALL) …

In the search for new metal complexes with antitumor potential, two dithiocarbazate ligands
derived from 1, 1, 1-trifluoro-2, 4-pentanedione (H2L1) and (H2L2) and four Ni (II) …

Super enhancers (SEs) are large clusters of transcriptional enhancers driving the
expression of genes crucial for defining cell identity. In cancer, tumor‐specific SEs activate …

B-cell acute lymphoblastic leukemia (B-ALL) is a malignant tumor originating from B-lineage
lymphoid precursor cells. The incidence of B-ALL is about 80% in childhood acute leukemia …

The dysregulation of alternative splicing (AS) is increasingly recognized as a pivotal player
in the pathogenesis, progression, and treatment resistance of B-cell acute lymphoblastic …

Background IGH:: DUX4 is frequently observed in 4% B‐cell acute lymphoblastic leukaemia
patients. Regarding the IGH:: DUX4‐driven transactivation and alternative splicing, which …

Objective. This study investigated the types and significance of mutant genes in children with
acute lymphoblastic leukemia (ALL). Methods. The gene sequencing data of 89 ALL …

In this issue of Blood, Thorsson et al report a comprehensive single-cell multiomics analysis
of 23 childhood B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) cases, identifying …

RAG1 is an abbreviation for recombination activating gene-1 which is the cornerstone in the
process of V (D) J recombination. The process enables our immune system to produce an …

Objective. This study investigated the types and significance of mutant genes in children with
acute lymphoblastic leukemia (ALL). Methods. The gene sequencing data of 89 ALL …