Oxidative stress occurs through an imbalance between the generation of reactive oxygen
species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly …

Skin aging is one of the most evident signs of human aging. Modification of the skin during
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure
through direct interactions of radiation with target macromolecules or via products of water …

The multidifferentiation ability of mesenchymal stem cells holds great promise for cell
therapy. Numerous studies have focused on the establishment of differentiation protocols …

Exposure of eukaryotic cells to ionizing radiation (IR) results in the immediate formation of
free radicals that last a matter of milliseconds. It has been assumed that the subsequent …

Mitochondrial respiratory function is impaired in the target tissues of patients with
mitochondrial diseases and declines with age in various human tissues. It is generally …

Mitochondria do not only produce less ATP, but they also increase the production of reactive
oxygen species (ROS) as byproducts of aerobic metabolism in the aging tissues of the …

Aging is commonly associated with a structural deterioration of skin that compromises its
barrier function, healing, and susceptibility to disease. Several lines of evidence show that …