Abstract The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the
cluster and its members has been increasing steadily and the number of publications has …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

The role of miR-124 on the expression of β-site APP cleaving enzyme 1 (BACE1), an
important cleavager of amyloid precursor protein that plays a pivotal role in the β-amyloid …

Regulation of amyloid-β (Aβ) precursor protein (APP) expression is complex. MicroRNAs
(miRNAs) are expected to participate in the molecular network that controls this process. The …

Alzheimer disease (AD) results, in part, from the excess accumulation of the amyloid-β (Aβ)
peptide as neuritic plaques in the brain. The short Aβ peptide is derived from the large …

J. Neurochem.(2011) 116, 240–247. Abstract The β‐amyloid peptide that accumulate in
Alzheimer's disease (AD) brain derive from proteolytic processing of the amyloid precursor …

The full repertoire of regulatory interactions utilized by human cells to control expression of
amyloid-β precursor protein (APP) is still undefined. We investigated here the contribution of …

The vast majority of Alzheimer's disease (AD) are late-onset forms (LOAD) likely due to the
interplay of environmental influences and individual genetic susceptibility. Epigenetic …

Circulating microRNA expression levels can serve as diagnostic/prognostic biomarkers in
several types of malignant tumors; however, to our knowledge, there have been reports …

Background APP expression misregulation can cause genetic Alzheimer's disease (AD).
Recent evidences support the hypothesis that polymorphisms located in microRNA (miRNA) …