Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Background There is an expanding field of research investigating the benefits of medicines
with multiple mechanisms of action across neurological disorders. N‐acetylcysteine (NAC) …

N-acetylcysteine (NAC) has been used as a direct scavenger of reactive oxygen species
(hydrogen peroxide, in particular) and an antioxidant in cancer biology and immuno …

Rampant phospholipid peroxidation initiated by iron causes ferroptosis unless this is
restrained by cellular defences. Ferroptosis is increasingly implicated in a host of diseases …

Biomarker-guided treatments are needed in psychiatry, and previous data suggest oxidative
stress may be a target in schizophrenia. A previous add-on trial with the antioxidant N …

The purpose of the present investigation was to formulate NAC (N-acetylcysteine)-loaded
chitosan (CH)-coated liposome aiming at obtaining an effective formulation able to ensure a …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by the progressive loss of motor neurons, for which current treatment options …

Drug addiction is a chronic, relapsing brain disorder. Multiple neural networks in the brain
including the reward system (eg, the mesocorticolimbic system), the anti-reward/stress …

There is a clear and pressing need to expand pharmacotherapy options for substance use
disorders (SUDs) in order to improve sustained abstinence outcomes. Preclinical literature …

Cataracts, one of the leading causes of preventable blindness worldwide, refers to lens
degradation that is characterized by clouding, with consequent blurry vision. As life …