Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

Cholesterol is a fundamental molecule necessary for the maintenance of cell structure and is
vital to various normal biological functions. It is a key factor in lifestyle-related diseases …

Deregulated cell proliferation is an established feature of cancer, and altered tumor
metabolism has witnessed renewed interest over the past decade, including the study of …

A comprehensive summary of more than 450 estrogenic chemicals including estrogenic
endocrine disruptors is provided here to understand the complex and profound impact of …

To date, estrogen is the only known endogenous estrogen receptor (ER) ligand that
promotes ER+ breast tumor growth. We report that the cholesterol metabolite 27 …

Cholesterol is essential for cell function and viability. It is a component of the plasma
membrane and lipid rafts and is a precursor for bile acids, steroid hormones, and Vitamin D …

Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested
in the diet. By modulating the activity of many proteins [eg, liver X receptors (LXRs), oxysterol …

Over the last two decades, the prevalence of obesity, and metabolic syndromes (MS) such
as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), have …

Abstract Introduction Carcinoma-associated fibroblasts (CAFs) play a pivotal role in cancer
progression by contributing to invasion, metastasis and angiogenesis. Solid tumors possess …