Human idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder
that is primarily characterized by degeneration of the dopaminergic neurons of the …

This paper provides an overview of the compensatory mechanisms which come into action
during experimental and human parkinsonism. The intrinsic properties of the dopaminergic …

We have studied focal changes in dopaminergic function throughout the brain volume in
early and advanced Parkinson's disease by applying statistical parametric map** (SPM) …

OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) is a highly prevalent childhood
psychiatric disorder characterized by impaired attention, excessive motor activity, and …

Emerging evidence points to reactive glia as a pivotal factor in Parkinson's disease (PD) and
1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-lesioned mouse model of basal …

Orally administered levodopa remains the most effective symptomatic treatment for
Parkinson's disease (PD). The introduction of levodopa therapy is often delayed, however …

Parkinson's disease is characterized by the progressive loss of dopaminergic neurons in the
substantia nigra pars compacta. Symptoms do not appear until most nigral neurons are lost …

Parkinson's disease (PD) is a neurodegenerative disorder marked by severe motor deficits
and reduced striatal dopamine levels. PD patients also commonly exhibit cognitive flexibility …

Disease-modifying treatments remain an unmet medical need in Parkinson's disease (PD).
Such treatments can be operationally defined as interventions that slow down the clinical …

Dopaminergic lesions result in the acute loss of striatal dopamine content, the loss of
tyrosine hydroxylase-immunoreactive fibers, upregulation of preproenkephalin mRNA …