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[HTML][HTML] On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles
The administration of drugs to the central nervous system (CNS) is primarily controlled by
the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds …
the blood-brain barrier (BBB), a structure that prevents the passage of foreign compounds …
[HTML][HTML] Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies
CP Costa, JN Moreira, JMS Lobo, AC Silva - Acta Pharmaceutica Sinica B, 2021 - Elsevier
The management of the central nervous system (CNS) disorders is challenging, due to the
need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the …
need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the …
JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
A Sarapultsev, E Gusev, M Komelkova, I Utepova… - Molecular …, 2023 - Springer
The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …
as a cornerstone in cellular signaling, regulating physiological and pathological processes …
Cationic polymers as transfection reagents for nucleic acid delivery
Nucleic acid therapy can achieve lasting and even curative effects through gene
augmentation, gene suppression, and genome editing. However, it is difficult for naked …
augmentation, gene suppression, and genome editing. However, it is difficult for naked …
Recent advances in the treatment of Alzheimer's disease using nanoparticle-based drug delivery systems
P Poudel, S Park - Pharmaceutics, 2022 - mdpi.com
Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder.
Most existing treatments only provide symptomatic solutions. Here, we introduce currently …
Most existing treatments only provide symptomatic solutions. Here, we introduce currently …
Nasal delivery to the brain: harnessing nanoparticles for effective drug transport
The nose-to-brain drug-delivery system has emerged as a promising strategy to overcome
the challenges associated with conventional drug administration for central nervous system …
the challenges associated with conventional drug administration for central nervous system …
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform
The discovery of effective drugs for the treatment of neurodegenerative disorders (NDs) is a
deadlock. Due to their complex etiology and high heterogeneity, progresses in the …
deadlock. Due to their complex etiology and high heterogeneity, progresses in the …
Recent progress in nanocarriers for direct nose to brain drug delivery
Nose to brain drug delivery is considered as a viable option to deliver various therapeutic
agents with low cerebral bioavailability bypass blood-brain barrier (BBB). The drug …
agents with low cerebral bioavailability bypass blood-brain barrier (BBB). The drug …
Nanoparticles: A Hope for the Treatment of Inflammation in CNS
Neuroinflammation, an inflammatory response within the central nervous system (CNS), is a
main hallmark of common neurodegenerative diseases, including Alzheimer's disease (AD) …
main hallmark of common neurodegenerative diseases, including Alzheimer's disease (AD) …
Brain‐Penetration and Neuron‐Targeting DNA Nanoflowers Co‐Delivering miR‐124 and Rutin for Synergistic Therapy of Alzheimer's Disease
Q Ouyang, K Liu, Q Zhu, H Deng, Y Le, W Ouyang… - Small, 2022 - Wiley Online Library
Alzheimer disease (AD) is the leading cause of dementia that affects millions of old people.
Despite significant advances in the understanding of AD pathobiology, no disease modifying …
Despite significant advances in the understanding of AD pathobiology, no disease modifying …