When the damage is done: injury and repair in thymus function

S Kinsella, JA Dudakov - Frontiers in immunology, 2020 - frontiersin.org
Even though the thymus is exquisitely sensitive to acute insults like infection, shock, or
common cancer therapies such as cytoreductive chemo-or radiation-therapy, it also has a …

Infection-associated thymic atrophy

M Luo, L Xu, Z Qian, X Sun - Frontiers in immunology, 2021 - frontiersin.org
The thymus is a vital organ of the immune system that plays an essential role in thymocyte
development and maturation. Thymic atrophy occurs with age (physiological thymic atrophy) …

Thymus, undernutrition, and infection: approaching cellular and molecular interactions

W Savino, J Durães, C Maldonado-Galdeano… - Frontiers in …, 2022 - frontiersin.org
Undernutrition remains a major issue in global health. Low protein-energy consumption,
results in stunting, wasting and/or underweight, three deleterious forms of malnutrition that …

Acute thymic involution and mechanisms for recovery

AR Ansari, H Liu - Archivum Immunologiae et Therapiae Experimentalis, 2017 - Springer
Acute thymic involution (ATI) is usually regarded as a virulence trait. It is caused by several
infectious agents (bacteria, viruses, parasites, fungi) and other factors, including stress …

Protein malnutrition promotes dysregulation of molecules involved in T cell migration in the thymus of mice infected with Leishmania infantum

M Losada-Barragán, A Umaña-Pérez… - Scientific Reports, 2017 - nature.com
Protein malnutrition, the most deleterious cause of malnutrition in develo** countries, has
been considered a primary risk factor for the development of clinical visceral leishmaniasis …

Thymic atrophy induced by Plasmodium berghei ANKA and Plasmodium yoelii 17XL infection

GM Corral-Ruiz, MJ Pérez-Vega, A Galán-Salinas… - Immunology …, 2023 - Elsevier
The thymus is the anatomical site where T cells undergo a complex process of
differentiation, proliferation, selection, and elimination of autorreactive cells which involves …

Insight into mRNA and its regulating pathways in the susceptibility and resistance to malaria infection by RNA sequencing

P Kataria, A Chaudhary, R Chauhan, M Kalkal… - 2023 - researchsquare.com
Background: Malaria is a severe febrile sickness transmitted by Plasmodium parasites.
During murine malaria infection, the host immune response exhibits distinct variations in …

Plasticity in Interferon Responses Modulates T-Cell Immunity in Parasitic Infections: Periphery to Thymus

L Thakur, N Akhtar, A Jain, H Parkash… - Innate Immunity in …, 2020 - books.google.com
Parasitic infections are the major threat prevalent in tropical and subtropical regions
throughout the world. Different parasitic infections take a huge toll on mortality and morbidity …

Mechanisms Underlying Mycobacterium Avium Infection-Induced Thymic Atrophy

R de Melo Miranda - 2019 - search.proquest.com
A atrofia tímica ocorre naturalmente a partir da puberdade. No entanto, a atrofia tímica
prematura pode ter um impacto negativo no sistema imunitário. A infeção por vários agentes …

Mechanisms underlying Mycobacterium avium infection-induced thymic atrophy

RM Miranda - 2019 - repositorium.sdum.uminho.pt
Thymic atrophy naturally occurs after puberty. However, premature thymic atrophy might
weaken the immune system. Infection by several pathogenic microorganisms induces …