Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease
In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …
technically challenging beginnings to become common laboratory methods capable of …
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches
O Menyhárt, B Győrffy - Cancer and Metastasis Reviews, 2020 - Springer
Medulloblastoma (MB) is the most common malignant childhood tumor of the brain.
Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy reduced …
Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy reduced …
Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level
S Godbole, H Voß, A Gocke, S Schlumbohm… - Nature …, 2024 - nature.com
Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and
clinically heterogenous. The application of omics technologies—mainly studying nucleic …
clinically heterogenous. The application of omics technologies—mainly studying nucleic …
New developments in the pathogenesis, therapeutic targeting, and treatment of pediatric medulloblastoma
Simple Summary Medulloblastoma is the most common pediatric brain tumor, comprising
one-third of all pediatric brain tumors, and originating in the posterior fossa of the brain. The …
one-third of all pediatric brain tumors, and originating in the posterior fossa of the brain. The …
Clinical and mutational profiles of adult medulloblastoma groups
Adult medulloblastomas are clinically and molecularly understudied due to their rarity. We
performed molecular grou**, targeted sequencing, and TERT promoter Sanger …
performed molecular grou**, targeted sequencing, and TERT promoter Sanger …
Hedgehog pathway inhibitors against tumor microenvironment
Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast,
pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been …
pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been …
Molecular stratification of medulloblastoma: clinical outcomes and therapeutic interventions
T Sursal, JS Ronecker, AJ Dicpinigaitis… - Anticancer …, 2022 - ar.iiarjournals.org
Medulloblastoma (MB) is the most common malignant pediatric posterior fossa tumor.
Recent genetic, epigenetic, and transcriptomic analyses have classified MB into three …
Recent genetic, epigenetic, and transcriptomic analyses have classified MB into three …
Subgroup-specific diagnostic, prognostic, and predictive markers influencing pediatric medulloblastoma treatment
S Ray, NK Chaturvedi, KK Bhakat, A Rizzino… - Diagnostics, 2021 - mdpi.com
Medulloblastoma (MB) is the most common malignant central nervous system tumor in
pediatric patients. Mainstay of therapy remains surgical resection followed by craniospinal …
pediatric patients. Mainstay of therapy remains surgical resection followed by craniospinal …
The neurodevelopmental and molecular landscape of medulloblastoma subgroups: Current targets and the potential for combined therapies
Simple Summary Medulloblastoma is the most common malignant brain tumor in the
pediatric population. Despite the utilization of aggressive treatment modalities, including …
pediatric population. Despite the utilization of aggressive treatment modalities, including …
Exploring the molecular complexity of medulloblastoma: implications for diagnosis and treatment
JS Rechberger, SA Toll, WJF Vanbilloen, DJ Daniels… - Diagnostics, 2023 - mdpi.com
Medulloblastoma is the most common malignant brain tumor in children. Over the last few
decades, significant progress has been made in revealing the key molecular underpinnings …
decades, significant progress has been made in revealing the key molecular underpinnings …